Traditional photodynamic therapy (PDT) is dependent on externally applied light and oxygen, and the depth of penetration of these factors can be insufficient for the treatment of deep infections. The short half‐life and short diffusion distance of reactive oxygen species (ROS) also limit the antibacterial efficiency of PDT. Herein, we designed a targeting singlet oxygen delivery system, CARG‐Py, for irradiation‐free and oxygen‐free PDT. This system was converted to the “singlet oxygen battery” CARG‐1O2 and released singlet oxygen without external irradiation or oxygen. CARG‐1O2 is composed of pyridones coupled to a targeting peptide that improves the utilization of singlet oxygen in deep multidrug‐resistant bacterial infections. CARG‐1O2 was shown to damage DNA, protein, and membranes by increasing the level of reactive oxygen inside bacteria; the attacking of multiple biomolecular sites caused the death of methicillin‐resistant Staphylococcus aureus (MRSA). An in vivo study in a MRSA‐infected mouse model of pneumonia demonstrated the potential of CARG‐1O2 for the efficient treatment of deep infections. This work provides a new strategy to improve traditional PDT for irradiation‐ and oxygen‐free treatment of deep infections while improving convenience of PDT.
For optimal management and automatic supervision of the multi-fan and multi-station mine ventilation system, a certain number of monitoring points should be allocated in proper sites so as to provide necessary information reflecting the system’s operation status, which is an important part of on-line optimization management. The monitoring points’ setting is related to its number, location and network decomposition method. It’ll complicate the issue if taking the three factors into consideration all together. Divide the issue into 2 parts. First, use Fibonacci method to determine the monitoring points’ number without considering the location and network decomposition method. Second, determine the optimal location, and then get the optimal decomposition and maximum modulus difference. The application indicates it makes the problem easier to solve without much calculation.
Firstly, the causes of mine air flow instability were analyzed in this paper, then the paper applied fuzzy mathematics method and got construction method of the membership function of airflow stability. Wind resistance of shaft and lane, natural wind pressure, operating conditions of fan and other random disturbance conditions are defined by membership function of relative stability degree of mine airflow. This paper provided a quantitative analysis method for the mine airflow stability.
Expert systems, or knowledge based systems, are programs in which the answer to a user-posed question is reached by logical or plausible inference rather than strictly by calculation, although calculation routines can form a major part of an expert system. Based on the integration of expert system technology and optimization technology, an intelligent computer aided design method for mine ventilation systems is proposed in this paper. Firstly, the structure and control algorithm of the intelligent design system are explored. Secondly, the knowledge types required for the mine ventilation expert system and the acquiring method of knowledge are discussed. Finally, the inference method of this expert system is put forward.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.