Undertaking my PhD at Nanyang Technological University has been both stimulating and enriching. I would like to thank the following people who have made this experience such an enjoyable one: Prof Klaus Karjalainen for his mentorship and invaluable expert advice. I am ever so grateful that he has given me the freedom to cultivate my ideas. Prof Christiane Ruedl for her kind concern and suggestions on how I can improve my work. Dr Piotr Tetlak who showed me the ropes around the lab and was actively involved in teaching and guiding me through the mouse transgenesis work.
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