High expression of the inhibitory receptor programmed death ligand 1 (PD-L1) on the surface of tumor cells have been found play a key role in tumor immune evasion in several human malignancies. However, the expression of PD-L1 on bone marrow mesenchymal stem cells (BMSCs) and whether the PD-1/PD-L1 axis is involved in the BMSCs versus T cell immune response in Multiple Myeloma (MM) remain poorly defined. In this study, we explored the expression of PD-L1 on BMSCs from MM patients and the role of PD-1/PD-L1 pathway in BMSCs-mediated regulation of CD8+T cells. We observed that the expression
High expression of the inhibitory receptor programmed death ligand 1 (PD-L1) on the surface of tumor cells have been found play a key role in tumor immune evasion in several human malignancies. However, the expression of PD-L1 on bone marrow mesenchymal stem cells (BMSCs) and whether the PD-1/PD-L1 axis is involved in the BMSCs versus T cell immune response in Multiple Myeloma (MM) remain poorly defined. In this study, we explored the expression of PD-L1 on BMSCs from MM patients and the role of PD-1/PD-L1 pathway in BMSCs-mediated regulation of CD8+T cells. We observed that the expression
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