Background: Metabolic syndrome (MS) is a cluster of metabolic risk factors including obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. MS in obese and type 2 diabetic (T2DM) subjects increases the risk of cardiovascular diseases (CVD). The objective of the present study is to estimate the prevalence of MS in obese T2DM subjects by using International Diabetes Federation (IDF) and National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) definitions. Methods: Obese T2DM (n=70) and normal healthy subjects (n=30) of both genders were selected from hospitals and diabetic centers of various localities of Karachi, Pakistan. The frequency of MS was estimated by utilizing criteria of the proposed definitions of IDF and NCEP-ATP III. Results: The prevalence of MS using IDF definition in obeseT2DM subjects was 85.7%. It is significantly higher (p≤0.05) in females (45.70%) as compared to males (30.0%). While, using NCEP-ATP III definition the overall prevalence of MS in obese T2DM subjects was 75.7%, the prevalence is significantly higher (p≤0.05) in females (47.1%) than males (38.6%). The development of MS was highly observed between 31-40 years of age under criteria of both definitions. Conclusion It is concluded that, the overall prevalence of MS is increasing significantly in obese T2DM subjects by using IDF and NCEP-ATP III definitions. However, IDF is more stringent for defining MS. Therefore, it is needed to initiate the preventive measures of a healthy lifestyle and emphasis should be given to reduce weight, increase physical activity, and increase intake of healthy low-glycemic-index foods.
Background: Diabetes mellitus (DM) is a highly prevalent non-communicable disease in the world. Current investigations evolved that oxidative stress is also a major risk factor to cause type 2 diabetes mellitus due to impairment of antioxidant defense system in various biological fluids. Methodology: In this cross-sectional study, 70 type 2 diabetes mellitus subjects and 30 normal healthy subjects of both genders were selected from various health care centers of Karachi, Pakistan for a study period of six months June 2017 -December 2017. The total antioxidant capacity (TAC) concentration was measured in serum by enzyme-linked immunosorbent assay (ELISA) technique using Caymans Antioxidant Assay. The biochemical parameters and anthropometric measurements were estimated by standardized methods. Data was analyzed using the statistical program Statistical Package for the Social Sciences (SPSS) version 10.0. Results: According to the study results TAC was significantly reduced (**0.05 ± 0.00 mmol /L) in type 2 diabetes mellitus subjects compared to normal healthy subjects (0.13 ± 0.02 mmol /L). It was noted that diastolic blood pressure (DBP), body mass index (BMI), and triglycerides (TG's) were significantly increased while high density lipoprotein-cholesterol (HDL-C) was significantly reduced in diabetic subjects than the comparative healthy individuals. Conclusion: This study showed that decreased levels of TAC and HDL-C in type 2 DM patients with increased levels of BMI, systolic blood pressure (SBP), fasting blood sugar (FBS), DBP, and total cholesterol (TC) which may cause oxidative stress and increase the progression of cardiovascular disease (CVD) and other metabolic diseases. Modifications in dietary habits and intake of antioxidant foods or supplements may diminish the process of oxidative stress which may consequently decrease CVD and other severe clinical outcomes.
Threats to the environment and the economy significantly worsened human health, greatly outweighing any gains associated with increasing food production. Numerous heavily fertilized crops are used as animal feed, contributing to global food inequalities and unbalanced diets, even in wealthy countries. Hazardous fertilizers have been linked to an excessive burden of communicable and non-communicable diseases, which significantly increase yields and pose considerable environmental and public health risks. The rate at which nitrogen fertilizers are applied is closely related to the buildup of toxins in the surrounding area, groundwater, and leafy and root crops. Consumption of diets including these ingredients has contributed to a significant risk to human health.
Background Informal caregivers are those who care for children without getting paid. They are often more prone to stress due to their extra daily tasks which leads to burnout. This study aimed to determine the frequency and associated risk factors of burnout among informal caregivers of children with disabilities in Karachi. Methodology A cross‐sectional study was done in 10 rehabilitation institutes of Karachi with 310 mothers of children with disabilities from infancy till 18 years of age in 2019. Pretested questionnaire was administered to collect data in which 31 mothers were interviewed through convenience sampling from each rehabilitation institute. To assess burnout, the Maslach Burnout Inventory (MBI) was used. Association of different variables of study participants with the scores of its three subdimensions, Emotional Exhaustion (EE), Depersonalization (DP) and Personal Accomplishment (PA), were analysed using linear regression modelling. Results Mean EE score was high in 6.5% of the mothers while PA scores were low in 58.7% of the mothers. High EE with low PA (defined by our team as ‘burnout’) was found in 4.2% of the mothers, with none of them reporting high levels of DP. Linear regression analysis significantly predicted higher EE scores of mothers with more than one disabled child while lower EE scores were significantly predicted in highly educated mothers and mothers who spent more time in caregiving. Higher PA scores were also significantly predicted for highly educated mothers. DP scores were significantly predicted to be higher in mothers who had highly educated husband/guardian, employed mothers and those living in joint families whereas they were significantly predicted to be lower in highly educated mothers. Conclusion We have identified that mothers who are less educated, have more than one child with disability and who live in joint families will need extra support and input to prevent burnout.
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