One‐step synthesis of highly substituted pyridines via a multicomponent reaction of structurally diverse aldehydes with various thiols and malononitrile using deep eutectic solvent (DES) as green reaction media and catalyst is presented. This catalyst‐free, cost‐effective, and environmentally benign protocol utilizes recyclable reaction media, it is amenable to large scale production without significant loss in efficiency giving the desired compounds in short reaction times with moderate to good yields (60–82%). The inexpensive DES showed excellent recyclability using a simple recovery and reuse system without loss of parent catalytic activity even after three cycles.
Adaptation of all‐in‐one ionic systems with ionic liquids (ILs) serving as solvent, reactant, and catalyst is an innovative approach in the organic synthesis. Mild and bio clean choline based ILs as all‐in‐one systems (solvent, reagent, and catalyst) were developed via a simple metathesis approach and were applied on the ring‐opening reaction of epoxides. Sustained transformation of various epoxides using choline cyanide, azide, and hydroxide ILs delivered a neat, efficient and convenient protocol for the synthesis of β‐substituted alcohols in moderate to high yields (64‐97 %) with excellent activity and selectivity as confirmed by nuclear magnetic resonance (NMR) spectroscopic data.
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