Background. Thalassemia is one of the most common genetic hematologic disorders in the world. Despite outstanding achievements in prenatal diagnosis and a decrease in the number of patients, thalassemia is still a significant issue in most parts of the world, especially in the Mediterranean countries. Understanding the factors associated with this condition is crucial to help clinicians and policymakers provides social and medical support for patients to facilitate their lives. This study aims to appraise the quality of life (QoL) and its related paraclinical factors in Iranian transfusion-dependent thalassemia patients. Methods and Materials. This study is a cross-sectional study performed in the thalassemia clinic of Imam-Ali Hospital, Karaj, Iran. The demographic, clinical, and laboratory data of 100 patients with transfusion-dependent thalassemia were recorded. The patients’ QoL was measured by the World Health Organization Quality of Life Instruments Brief (WHOQOL-BREF) version questionnaire. The results were analyzed using SPSS software. Results. This study demonstrated that all four features of life are influenced in transfusion-dependent thalassemia patients. Also, higher educational status and lower serum ferritin levels were associated with better scores in assessing the QoL. On the other hand, an elevated level of AST (aspartate transaminase), ALT (alanine transaminase), and FBS (fasting blood sugar) are associated with lower scores. Conclusion. All features of QoL are correlated to the patients’ laboratory findings. Our data suggest that managing patients’ laboratory indices is attributed to their higher QoL. We also suggest regular screening of patients’ QoL to manage disease complications more efficiently.
Background: Parkinson's disease is a chronic and progressive disease in which patients show symptoms of psychiatric diseases such as anxiety and depression leading to decreased quality of life. So far, few studies have been done in this field in Iran. Methods: The study is a cross-sectional study that investigates the prevalence of anxiety and depression and their related factors in patients with Parkinson's disease. In this study, 74 patients with Parkinson's disease and 74 healthy individuals were evaluated and using by Beck's Depression and Anxiety Inventories. Results: The prevalence of depression and anxiety in patients with Parkinson's was 37.83% and 78.38%, respectively. The mean score of depression and anxiety was significantly higher in the patient group (P<0.001). Older age, female sex, a higher level of education and a longer duration of illness were significantly associated with more depression and anxiety (P<0.05). Multiple regression models showed that age was a predictive factor in depression. With respect to anxiety, age and duration of the disease were predictive factors. Conclusion:The severity of depression and anxiety were significantly higher in patients with Parkinson's disease compared to healthy individuals. Age and duration of the disease play a significant role in predicting the severity of depression and anxiety in such patients.
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