The aim of this study was to assess the correlation between thallium-201 (201Tl) uptake and proliferative activity measured using the proliferating cell nuclear antigen labelling index (PCNA-LI) in brain tumours. Twenty-nine patients with brain tumours were included in this study. Of these, seven were diagnosed with meningioma, 13 had high grade glioma (HGG) and nine had low grade glioma (LGG). A 210Tl single photon emission computed tomography study was performed on all patients before operation, and 201Tl uptake index (UI) and retention index (RI) values were calculated. Cell proliferation was determined by PCNA. While all of the HGGs and meningiomas showed intense 201Tl accumulation on visual interpretation, eight of the nine LGGs did not show accumulation of 210Tl at the tumour site. 201Tl UI values were 3.23+/-0.89 and 2.67+/-0.66 in HGG, 1.27+/-0.18 and 1.23+/-0.09 in LGG, and 4.35+/-1.60 and 2.52+/-0.78 in meningioma on early and delay images, respectively. There was a statistical difference between the 201Tl UI in HGG and LGG. PCNA-LI values were 16.72+/-6.15%, 1.63+/-0.81% and 2.00+/-1.88% in HGG, LGG and meningioma, respectively. The PCNA-LI in HGG was significantly higher than in LGG and meningioma. While the correlation coefficient between the 201Tl UI and the PCNA-LI was 0.94 in gliomas (n=22), there was no correlation in meningiomas. No statistically significant correlation was found between the RI and the PCNA-LI in gliomas. The presence of a strong positive correlation between 201Tl uptake and PCNA-LI indicates that 201Tl uptake can predict the proliferative activity of the glioma.
Background: In this study, we wanted to draw attention to the spontaneous pneumomediastinum which rarely seen and to share our experiences. Materials and Methods: Between April 2016-April 2018, we retrospectively evaluated 12 patients who were hospitalized and treated with SPM diagnosis at Health Practice and Research Center. Results: Of the 12 patients with spontaneous pneumomediastinum, 9 (75%) were male and 3 (25%) were female. Patients had a mean age of 30.5 years (range 15-42 years), 2 patients admitted to the emergency service with swelling and dyspnea complaints, 1 patient with cough and vomiting, 1 patient with cough and chest pain, 3 patients with dyspnea and chest pain, 3 patients with sore throat and chest pain, 2 patients with swelling in the neck after the tooth extraction. 6 (50%) of the patients had a smoking history. Conclusions: Spontaneous pneumomediastinum is a disease that is seen rarely in emergencies and should be treated. Sometimes life-threatening complications may develop. Other disorders in differential diagnosis should be eliminated in spontaneous pneumomediastinum.
Although there are a lot of data on intrathoracic and extrathoracic injuries associated with adult sternal fractures and how to manage them; but there is not much data on diagnosis and treatment protocols, since they are rare in children. If the child patient has a sternal fracture, he/she probably had a high-energy trauma, so it should be carefully examined whether if there is an accompanying intrathoracic or extrathoracic injury. In this study, we aimed to determine the demographic data, accompanying injuries, treatment modalities and results in children who were admitted to the emergency trauma unit of our hospital and diagnosed with sternal fracture.
Objective: To determine the association of alpha-1 antitrypsin deficiency (AATD) in patients diagnosed with primary spontaneous pneumothorax (PSP), the presence of the SERPINA 1 gene, and the phenotype in patients with low enzyme values.
Background: This study aims to investigate the role of telomerase activity in the risk of primary spontaneous pneumothorax, which is most frequently encountered in the practice of thoracic surgery.
Methods: A total of 61 patients (56 males, 5 females; median age: 29.4 years; range, 17 to 43 years) who underwent treatment for primary spontaneous pneumothorax and 19 age- and sex-matched healthy controls (10 males, 9 females; median age: 29.1 years; range, 23 to 43 years) were included in this prospective study between January 2018 - August 2018. Telomerase activity was evaluated with enzyme-linked immunosorbent assay. The correlation between telomerase activity and clinical and demographic parameters was examined.
Results: The mean serum telomerase level was 3.4±0.6 ng/mL in the primary spontaneous pneumothorax group and 1.9±0.5 ng/mL in the control group, indicating significantly higher levels in the patient group (p<0.001). There was no significant association between the telomerase levels and presence of blebs and/or bullae on thoracic computed tomography, extent of pneumothorax, laterality (right, left, or bilateral), and pack years of cigarette smoking.
Conclusion: Telomerase levels of patients with primary spontaneous pneumothorax are significantly higher than healthy individuals. Future genetic studies may ultimately clarify a potential relationship between primary spontaneous pneumothorax and short telomere syndrome.
Background: It was aimed to retrospectively examine the data of patients who underwent catheter thoracostomy to determine their demographic and clinical characteristics and to evaluate the effectiveness of the procedure.
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