Original scientific paperThe objective of this study is to see for micro-milling of Ti6Al4V in the different parameters, how wear occurs on the face of the tool and how to evolve cutting temperature, forces, and chip formations with FEM. The effects of dry, liquid coolant and LN2-based cryogenic cooling applications at 50,100,150 m/s cutting speeds and 1,2,3 μm/dev feed rate were compared in micro-milling of Ti6Al4V alloy. At different parameters, internal and workpiece-cutting edges cryogenic (wacec) are simulated temperatures were observed. Cryogenic cooling, dry and liquid coolant applications perceived that tool wear, chip formation, strain, stresses, and shear forces interpreted with the FEM. Also, a mesh model based on Arbitrary Lagrangian-Eulerian (ALE) simulations and the Johnson-Cook Plasticity model for material plasticity failure criterion are used in this study. As a result, indicated that at the cutting velocity of 100 m/min, cryogenic cooling on the workpiece and cutting edges has caused into decreasing %57 of cutting temperature also by %54 lower tool wear was observed on the internal tool cryogenic, by %15 the shear stresses decreased on wacec in comparison to dry cutting.