Plant-based products have expanded to include cancer immunotherapy, which has made great strides over recent years. Plants are considered inexpensive and facile production platforms for recombinant monoclonal antibody (mAb) due to the latest advancements and diversification of transgenic techniques. Current human biologics, including those based on mAbs produced by fermentation technologies using primarily mammalian cell cultures, have been replaced by plant-produced mAbs, which are cost effective, more scalable, speedy, versatile, and safer. Moreover, the use of animals for antibody production is always a question of ethical unambiguity, and the suitability of animal models for predicting the immunogenicity of therapeutic mAbs in humans and transposition of the immunogenic potential of therapeutic antibodies in animals to the human situation has no scientific rationale. Quite a few plant-based mAbs are approved for the treatment of cancer, ranging from tumors to hematological malignancies. This review focuses on the cutting-edge approaches for using plant-derived mAbs to suppress or prevent cancers. It also discusses the avenues taken to prevent infection by oncogenic viruses, solid tumors, lymphomas, and other cancerous conditions using mAbs. The review emphasizes the use of a plant-derived monoclonal antibody as a premier platform to combat cancer.

This study was conducted in the Khulna metropolitan city to determine the status of noise pollution at major traffic intersections and assess the possible effect of noise on regular noise afflicted people. For this research, five busiest roadways and traffic intersections; two mixed zone and three commercial zones were selected purposively and 'ST-8850 Sound Level Meter' was used to record the noise pressure level. Average noise pressure level and some noise parameters (Leq, L10, L50, L90, and Lnp) were measured at different shifts in each location both on working days and holidays. The result evidently specified that noise level in all major traffic circles of Khulna metropolitan city was much higher than the recommended threshold of acceptable noise level set by the Department of Environment (DOE) of Bangladesh. It was observed that the mixed area (Sonadanga, Gollamari) tends to have a higher average noise level than those of the commercial area (Shibbari, Notunrasta, Dakbangla). The noise pollution level (Lnp) in mixed areas varied from 92.77 dB (A) to 104.74 dB(A) on working days and 86.9 dB(A) to 105.5 dB(A) on holidays. On working days, the highest Leq was observed 92.65 ± 4.15 dB(A) in Sonadanga (mixed area), whereas the lowest was 85.13 ± 2.83 dB(A) in Dakbangla (commercial area). However, on holidays the highest level of Leq was found 90.41 ± 2.25 dB(A) in Sonadanga, while the lowest levels were 80.43 ± 3.20 dB(A) in Dakbangla. One-way ANOVA with LSD post-hoc test results illustrated that on working days there was a significant difference between the noise pollution levels (NPL) in different shifts of day time (F = 8.412, p < .05). The respondents of the study area addressed that they were the most affected by annoyance (70%), headache (62%), and hearing loss (46%) due to regular exposure to the traffic noise. Therefore, it is recommended to enhance awareness regarding the cause and effect of noise pollution among the noise producers and oppressed people. Subsequently, administrative measures have to take to attenuate noise pollution and indemnify the quality health of the citizens.

Ovarian cancer is one of the most prevalent malignancies and is the deadliest among all gynecologic cancers. Although tremendous progress has been made on cancer biology and tumour treatment, knowledge on the mechanisms of cancer development including that for ovarian cancer remains incomplete. Thus, in addition to cancer prevention it is urgent to develop effective therapeutic modalities even for the advanced stage and drug-resistant forms of the disease with ovarian cancer being no exception. Multistep tumourigenesis is activated by various environmental carcinogens, inflammatory agents and tumour promoters. Carcinogens modulate the transcription factors, anti-apoptotic and pro-apoptotic proteins, protein kinases, cell cycle proteins, cell adhesion molecules and growth factor signaling pathways and thus produce malignancies. Phytochemicals exert their antitumour effects by numerous signaling pathways which in turn affect multiple steps in the various cellular pathways leading to tumourigenesis. Antitumour active phytochemicals have cytotoxic action in all ovarian cancer cell lines with comparable or greater activity in the resistant cell lines than in the parent cell line. As phytochemicals have been a part of human diet without toxic effects, they are likely to protect normal cells and tissues caused by the direct and bystander effects of platinum drugs. Therefore, it is quite logical to assume that phytochemicals possessing both cancer preventive and therapeutic attributes, can be ideal candidates in cancer prevention and synergistic outcomes from their combination with targeted therapy.

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