The combination of recessively inherited cone-rod dystrophy (CRD) and amelogenesis imperfecta (AI) was first reported by Jalili and Smith in 1988 in a family subsequently linked to a locus on chromosome 2q11, and it has since been reported in a second small family. We have identified five further ethnically diverse families cosegregating CRD and AI. Phenotypic characterization of teeth and visual function in the published and new families reveals a consistent syndrome in all seven families, and all link or are consistent with linkage to 2q11, confirming the existence of a genetically homogenous condition that we now propose to call Jalili syndrome. Using a positional-candidate approach, we have identified mutations in the CNNM4 gene, encoding a putative metal transporter, accounting for the condition in all seven families. Nine mutations are described in all, three missense, three terminations, two large deletions, and a single base insertion. We confirmed expression of Cnnm4 in the neural retina and in ameloblasts in the developing tooth, suggesting a hitherto unknown connection between tooth biomineralization and retinal function. The identification of CNNM4 as the causative gene for Jalili syndrome, characterized by syndromic CRD with AI, has the potential to provide new insights into the roles of metal transport in visual function and biomineralization.
Objectives: This study aimed to compare the shear bond strength (SBS) of self-adhesive and conventional flowable composites and resin-modified glass-ionomer cement (RMGIC) to primary dentin. Materials and Methods: In this in vitro, experimental study, the buccal surface of 48 primary canine and first molar teeth was longitudinally sectioned to expose dentin. The teeth were randomly divided into three groups (n=16) of 37.5% phosphoric acid+ OptiBond+ Premise Flow composite (group 1), Vertise Flow composite (group 2) and RMGIC (group 3). A plastic cylindrical mold was placed on the exposed dentin and filled with restorative materials. The samples were then immersed in distilled water at 37°C for 24 hours, subjected to 1000 thermal cycles between 5-55°C and underwent SBS test. The mode of failure was determined under a stereomicroscope. Data were analyzed using one-way ANOVA and Tukey’s test. Results: A significant difference was noted in SBS of the groups (P<0.05). The SBS of conventional flowable composite was significantly higher that of RMGIC and self-adhesive flowable composite (P<0.05). The difference in SBS of RMGIC and self-adhesive flowable composite was not significant (P>0.05). Failure at the dentin-restoration interface (adhesive failure) had the highest frequency in groups 1 and 2. The frequency of adhesive failure was 100% in group 3. Conclusions: Within the limitations of this study, the conventional flowable composite yielded the highest SBS to primary dentin. Self-adhesive flowable composite and RMGIC showed the lowest SBS with no significant difference with each other.
Selective immunoglobulin A (IgA) deficiency is the most common of the primary immunodeficiencies with a frequency of 1/300-1/3000, depending on the screened population. As secretory IgA (SIgA) has a protective role in mucosal surfaces from invasion of microorganisms, it is thought that IgA-deficient subjects are susceptible to periodontal diseases and oral manifestations. Previous studies show contradictory results, concerning the involvement of the individuals' periodontium with IgA deficiency. The aim of this study was to investigate and compare the oral manifestations in IgA-deficient subjects with controls. Eleven selective IgA-deficient subjects aged 3-18 years with serum IgA levels <10 mg dl(-1) and 11 age-sex-matched healthy children as the controls entered the study. Oral mucosal investigation, dental caries, plaque accumulation and periodontal status were assessed. Serum immunoglobulin levels were measured by single radial immunodiffusion (SRID) method. Saliva immunoglobulins and secretory component levels were measured by enzyme linked immunosorbent assay (ELISA) methods. IgA-deficient patients had serum and saliva IgA levels less than 10 mg dl(-1) and 10 microg ml(-1), respectively, but other serum immunoglobulin levels were normal and saliva immunoglobulin M (IgM) levels were increased, compared with controls. There were no significant differences in oral manifestations between IgA-deficient subjects and controls, which may be a result of compensatory increase of saliva IgM or other non-immunological defence factors in saliva. Thus, it is not necessary to evaluate IgA and SIgA in all the patients with oral and dental lesions and it is thought that it is better to investigate other factors.
Background: Diastema is one of the many esthetic abnormalities due to various causes. One of which is abnormal frenulum. Objective: The aim of this study is to determine the prevalence of different types of labial frenum and their effect on median diastema in 3-6-year-old children in Tehran kindergartens. Materials and methods: This study was a cross-sectional one that was performed on 639 children aged 3-6 years by referring to kindergartens. Studying these children included oral examination under normal light with a tongue depressor in upright position. By lifting the patient's lip and performing a blanching test, it was determined whether or not a person has normal frenulum. Information was also provided about the presence or absence of median diastema in upper jaw and the type of frenum adhesion. Also, the central teeth in maxilla were carefully examined in terms of spacing and caries. Data were analyzed by descriptive and analytic statistical methods. In the analytic part we used the binomial logistic regression test and also in the descriptive section of the frequency, tables and graphs are presented. Conclusion:In this research, a total of 639 children were studied, 341 of which were male and 298 were female. Among these 214 people (33.5%) had abnormal frenum and 425 people (66.5%) had normal frenum. Frenum adhesion site for 52.9% of the people was observed in attached gingiva and for 19.9% of people was observed in the mucogingival junction and for 18.8% of people was observed in the interdental papilla and for 8.5% of people the site of frenulum was in depth of the palatal papilla, and there was no significant difference between two sexes in terms of prevalence of different types of maxilla labial frenum. The results showed that there is a significant relationship between high frenum and maxillary median diastema and there is no significant relationship between age and high frenum.
Aim This study aimed to assess the iron stain removal efficacy of three toothpastes in extracted primary teeth. Materials and methods In this in vitro study, 60 extracted sound primary teeth were selected, decoronated at the cementoenamel junction, and their pulp chambers were filled with a composite. The teeth were then immersed in ferrous sulfate solution and brushed 3,000 times in an automatic tooth-brushing machine using Colgate, whitening Crest, and conventional Crest dentifrices. Stain removal was done in four groups using a prophylaxis paste. Digital images were obtained from the teeth before and after brushing with dentifrices and the changes in color parameters were measured using Photoshop and iColor software programs. Changes in color parameters were statistically analyzed using one-way ANOVA while multiple comparisons were done by Tukey's test. Results The greatest change in chroma was observed in the prophylaxis group and then in the whitening Crest, Colgate, and conventional Crest (mean values of −65.2, −31.07, −21.27, and −0.73, respectively). Prophylaxis completely removed the stains. The greatest reduction in value occurred in conventional Crest, Colgate, and whitening Crest (−18.07, −12.23, and −0.4, respectively). In the L * a * b * system, the least reductions were noted in the whitening Crest, Colgate, and conventional Crest (mean values of −1.96, −3.92, and −3.37, respectively). Prophylaxis significantly improved tooth brightness (a mean increase of 4.26). Conclusion None of the toothpastes in this study were capable of effectively removing iron stains. Crest whitening toothpaste was slightly effective in this regard. Clinical significance Iron drops are routinely prescribed for children younger than 2 years of age to prevent iron deficiency and iron deficiency anemia. However, iron stains on teeth are a common concern for many parents. Finding toothpastes with greater efficacy for iron stain removal can help in this respect. How to cite this article Heidari A, Shahrabi M, et al. Efficacy of Three Toothpastes in Iron Stain Removal from Primary Teeth. Int J Clin Pediatr Dent 2019;12(1):10–14.
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