Obesity or overweight is a risk factor for several health disorders such as type 2 diabetes, hypertension, and certain cancers. Furthermore, obesity affects almost all body systems including the extracellular matrix (ECM) by generating a pro-inflammatory environment, which are associated with abnormal secretions of several cytokines or hormonal substances, for example, insulin-like growth factors (IGFs), leptin, and sex hormones. These chemical mediators most likely have a great impact on the ECM. Accumulating evidence suggests that both obesity and ECM can influence tumor growth and progression through a number of chemical mediators. Conversely, cells in the connective tissue, namely fibroblasts and macrophages, support and aggravate the inflammatory situation in obesity by releasing several cytokines or growth factors such as vascular endothelial growth factor, epidermal growth factor, and transforming growth factor-beta (TGF-β). A wide range of functions are performed by TGF-β in normal health and pathological conditions including tumorigenesis. Breast cancer in postmenopausal women is a classic example of obesity-related cancer wherein several of these conditions, for example, higher levels of pro-inflammatory cytokines, impairment in the regulation of estrogen and growth factors, and dysregulation of different ECM components may favor the neoplastic process. Aberrant expressions of ECM components such as matrix metalloproteinases or matricellular proteins in both obesity and cancer have been reported by many studies. Nonstructural matricellular proteins, viz., thrombospondins, secreted protein acidic and rich in cysteine (SPARC), and Cyr61-CTGF-Nov (CCN), which function as modulators of cell-ECM interactions, exhibit protean behavior in cancer. Precise understanding of ECM biology can provide potential therapeutic targets to combat obesity-related pathologies.
Abstract:A hospital based cross sectional study was carried out among the under-five children admitted to the longer stay wards (LSU) of the hospital of ICDDR,B to investigate the relationship between children's nutritional status and clinical recovery as well as sock, economic condition. Nutritional status was determined by anthropometric measurements. The study conducted on 94 children of 6-59 months, of whom 49 were malnourished and 49 were well nourished 64 of them were male and 35 were female. (It means that boy's are more sufferers in diarrhea than girls.) (Children's age come within a range of 6-59) month. Mother's education level was lower, 32.6% mothers were illiterate and 40% mothers of malnourished children were illiterate where, 25% mothers having well nourished child were illiterate. Most of the malnourished children's Family income was below TK. 5,000 per month for majority of the parents whereas, most of the well nourished children's family income was 8,000tk. It shows that, children having low family income are more likely malnourished than well nourished children. Family member was within 4 persons for majority of the well nourished children's households'. On the other hand family member was more than 5 in out of the malnourished households. Within their limited income; it was difficult to maintain a medium size family properly. Our study reveals that knowledge, attitude and practices of dietary pattern, health, sanitation and immunization of the malnourished children's family were lower than well-nourished children's family. Their nutritional knowledge was too low, compared with well nourished children's parents. In our study, Most of the parents of well-nourished children used to feed colostrums (80.6%) but Parents having malnourished children discarded colostrums (93.6%). Our study reveals that 64.4% malnourished children's mother has started complementary food in <2 months of age ,on the other hand majority of well-nourished children's mother gave their child complementary food at the age of 6-9 months. It has been seen that, the majority of well nourished children (62%) were immunized by taking all doses of vaccines. where as most of the malnourished children (49%) has not taken all doses as a result there immunity was lesser than well-nourished children. Most of the caregivers of well-nourished children (43.5%) knows that diarrhea causes by not giving immunization, on the other hand majority of caregiver of malnourished patients (31.9%) knows that main cause of diarrhea is infection by germs. The immunization status of well nourished children was quite satisfactory. 62% well nourished children and only 40% Mal nourished children was completely immunized. It has been seen that, ORS intake was higher in well-nourished children (172.2lml-on the 1 st day of hospitalization, compare to malnourished children. Stool output was higher in malnourished children 235.48 ml-on the 1 st day after admission. It shows that there is a co-relation between ORS intake, stool output and recovery period. It has...
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