Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop task and its relationship with positive and negative symptoms in early psychosis (EP, N = 88) and chronic schizophrenia (CHR-SZ, N = 38) patients. CHR-SZ patients showed reduced frontal, striatal, and parietal activation across incongruent and congruent trials compared to EP patients. Higher positive symptom severity was associated with reduced activation across both trial types in supplementary motor area (SMA), middle temporal gyrus and cerebellum in EP, but not CHR-SZ patients. Higher negative symptom severity was associated with reduced cerebellar activation in EP, but not in CHR-SZ patients. A negative correlation between negative symptoms and activation in SMA and precentral gyrus was observed in EP patients and in CHR-SZ patients. The results suggest that the neural substrate of positive symptoms changes with illness chronicity, and that cognitive control related neural circuits may be most relevant in the initial development phase of positive symptoms. These findings also highlight a changing role for the cerebellum in the development and later maintenance of both positive and negative symptoms.
Purpose: Our prior work indicates that a group-based cognitive training intervention can improve memory and attention in cancer survivors. This study examined potential for training transfer on two cognitive tasks and corresponding changes in neural activation patterns as measured by fMRI prior to and following the cognitive training intervention. Methods: Seven gynecologic cancer (ovarian, breast, uterine) survivors (mean age: 64 years, mean time since primary treatment: 7.2 years) underwent a 7-week cognitive rehabilitation intervention delivered in group format. Participants were evaluated with a comprehensive cognitive battery and two experimental cognitive tasks prior to and following treatment. A word pair task required participants to learn pairs of words and later indicate whether words had been seen before (Item condition) or whether words had been paired together at learning (Relational condition). A verbal working memory task required participants to learn a set of 3, 5, or 7 letters and confirm or deny the presence of a probe letter. Participants also underwent fMRI scanning during word pair and verbal working memory tasks prior to and following treatment. Results: Participants showed significant improvement following intervention in accuracy in the Relational condition, in which strong associations between presented word pairs were required for successful performance, t(3)=5.21, p< .05. By contrast, accuracy did not increase significantly in the Item condition following intervention, t(3)=.48, p=.66). There was also a significant improvement in accuracy for the intermediate load (5-item) condition of the verbal working memory task following intervention, t(3)=4.17, p<.05. fMRI analyses revealed activation in a frontoparietal network during both the word pairs and verbal working memory tasks. Future analyses will investigate changes in recruitment of this network following intervention. Conclusions: Cancer survivors show evidence of specific transfer of memory skills following a group-based cognitive training intervention as demonstrated by improvement on the word memory task- relational item. In addition, there was a trend toward improvement on a working memory task. Neuroimaging results suggest frontoparietal network involvement for the cognitive task as well as some indication of a more efficient neural response following training. These results suggest that cognitive training may have a beneficial impact on both behavioral measures of cognition as well as neural activation markers. Citation Format: H. Gray, M. K. Askren Thomas, K. Anderson, D. David, A. Singh, K. Murphy, S. Willis, H. Mendoza, M.M. Cherrier. Neurocognitive evaluation of a cognitive training intervention in ovarian and gynecologic cancer survivors [abstract]. In: Proceedings of the 10th Biennial Ovarian Cancer Research Symposium; Sep 8-9, 2014; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(16 Suppl):Abstract nr POSTER-CTRL-1205.
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