Non-steroidal anti-inflammatory drugs (NSAIDs) are thought to play a role in the process of muscle repair. However, the mechanism by which they function remains poorly understood. Recent studies have focused on the link between the COX-2 pathway of muscle repair and anti-inflammatory drugs. This article examines representative studies by Oak et al. (2014) and Lu et al. (2015), who have investigated this process in-depth and found differing results regarding the effects of COX inhibitors on the repair of skeletal muscle after injury. These studies also demonstrate that NSAIDs operate within the COX-2 pathway, which is a necessary pathway for muscle repair.