Thalassemias are inherited blood disorders that are found in high prevalences in the Mediterranean, Southeast Asia and the Pacific. These diseases provide varying levels of resistance to malaria and are proposed to have emerged as an adaptive response to malaria in these regions. The transition to agriculture in the Holocene has been suggested to have influenced the selection for thalassemia in the Mediterranean as land clearance for farming encouraged interaction between Anopheles mosquitos, the vectors for malaria, and human groups. Here we document macroscopic and microscopic skeletal evidence for the presence of thalassemia in both hunter-gatherer (Con Co Ngua) and early agricultural (Man Bac) populations in northern Vietnam. Firstly, our findings demonstrate that thalassemia emerged prior to the transition to agriculture in Mainland Southeast Asia, from at least the early seventh millennium BP, contradicting a long-held assumption that agriculture was the main driver for an increase in malaria in Southeast Asia. Secondly, we describe evidence for significant malarial burden in the region during early agriculture. We argue that the introduction of farming into the region was not the initial driver of the selection for thalassemia, as it may have been in other regions of the world.

The common wombat (Vombatus ursinus) is equipped with a set of physiological and morphological adaptations suited to a fossorial lifestyle. These allow wombats to engage in efficient scratch-digging and maintaining a low basal metabolic rate while living underground. While bone microstructure has been described for several subterranean animals, wombat bone histology has received very little attention to date. Here, we present preliminary insights into bone histology in modern adult V. ursinus (Mt Fairy, New South Wales) and Pleistocene fossil Vombatus sp. (Bakers Swamp, New South Wales) midshaft humeri. The modern sample was well preserved, allowing us to identify varying bone tissue types (woven, parallel-fibred, lamellar). The sample showed vascularity composed of primary and secondary osteons, and simple longitudinal and radial vessels. We also observed evidence for Haversian remodelling (i.e. localised replacement of pre-existing bone) and coarse compact cancellous bone within the inner cortex of the diaphysis. The fossil histology was poorly preserved, but likely showed bone matrix organisation similar to the modern specimen. We use these preliminary data to discuss hypotheses for wombat forelimb biomechanical and physiological microscopic adaptation to a burrow environment. We encourage future intraskeletal examination of microstructure in wombat populations to better inform their ecological adaptations and behaviour in palaeontological contexts.

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Historical records of mercury (Hg) deposition in lake sediments have commonly been used to monitor historic atmospheric concentrations. In the Australian environment, however, freshwater lakes are limited, restricting the region for which depositional archives of Hg can be derived. In this study we show that dendrochemistry can provide a record of atmospheric concentrations at very high resolution. We measured Hg concentrations in growth rings of two tree species from a site in western in Tasmania-Huon Pine (Lagarostrobus franklinii) and Celery Top Pine (Phyllocladus aspleniifolius). This region has been heavily mined over the past 150 years. Although much previous work has linked atmospheric Hg to gold mining, the evidence in this study suggests that copper smelters in Queenstown and Zeehan, not gold mining activities, were the main sources of Hg emissions to the atmosphere in this location. Huon Pine had significantly higher background Hg concentrations (x̅ = 5.62 ng/g) than Celery Top Pine (x̅ = 2.95 ng/g). No significant increase in Hg concentration during the peak copper smelting phase (1896 to 1935) was observed in Celery Top Pine, while a significant 1.4 fold-increase was observed in Huon Pine. Our results show that of species examined across the globe, Huon Pine is one of the most efficient bioaccumulators of Hg, making it a good proxy for tracking historical Hg emissions in western Tasmania. This ability to measure Hg in the environment is essential if Australia ratifies the Minamata Convention.

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