Objective: The present study was undertaken to assess liver function (using markers like SGPT, serum bilirubin, prothrombin time, serum albumin) in children suffering from Acute Lymphoblastic Leukemia. Materials & Methods: This study was carried out in the Department of Pediatric Hematology & Oncology, Dhaka Medical College Hospital, Dhaka, over a period 12 months from the day of approval of the protocol. All acute lymphoblastic leukaemia children admitted in Pediatric Hematology & Oncology Department in Dhaka Medical College Hospital and receiving chemotherapy of standard protocol for induction of remission were the study population. A total of outcome variable was hepatotoxicity resulting from chemotherapy given for induction of remission. Result: The mean age of the children was 4.4 years (range 2- 8 years). Males were a bit higher in the series with male to female ratio being 11:9. Liver function tests before therapy revealed that none of the children exhibited raised serum billirubin and only 2(4.5%) children had increased SGPT. However, 50% of the children had raised prothrombin and 43.2% had reduced serum . albumin. Liver function tests after therapy after induction of remission shows that 9(20.5%) children exhibited raised serum billirubin, the proportion of children with raised prothrombin remained almost same as before but the status of serum billirubin improved to some extent. However, proportion of children with raised SGPT was increased to 25%. Comparison of liver function in children after therapy during induction of remission with that before induction did not show any significant difference, except that the serum SGPT was significantly raised during induction of remission (p < 0.001). Conclusion: The study concluded that the current therapy for induction of remission of ALL cases does not produce any toxic effect on liver. Although, enzymes like SGPT take a sharp rise during induction of remission, it is transient and does produce any deleterious effect on liver. J Dhaka Medical College, Vol. 29, No.1, April, 2020, Page 33-37
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting multiple small symmetrical joints with extra-articular involvement. Altered blood mineral status is associated with the immune-inflammatory rheumatoid process. Reduced heart rate variability (HRV) is a predictor of sudden cardiac death in RA patients. So, the role of minerals for altered HRV needs investigation in RA. Objectives: To assess the relationship between HRV and serum zinc (Zn), magnesium and (Mg) levels in RA patients. Methods: This cross sectional study enrolled 60 female participants of 30-50 years of age. Among them 30 female RA patients were included in the study group and 30 age matched apparently healthy women constituted control group. Serum Zn, Mg levels were estimated by autoanalyzer and frequency domain parameters of HRV were recorded by a data acquisition device, Powerlab 8/35, AD Instruments, Australia followed by analysis with software, Lab chart. Statistical analyses were done by independent sample ‘t’ test and Pearson’s correlation coefficient test. Results: In this study, among frequency domain parameters of HRV, total power (TP), low frequency power(LF), high frequency power(HF), HF normalized unit(HF nu) were significantly lower (p<0.05) and LF normalized unit (LF nu), LF/HF ratio were significantly higher (p<0.05) in RA patients. In addition, significantly (p<0.05) lower levels of serum Zn and Mg were found in RA patients as compared to controls. But on correlation analysis, the HF nu showed significant positive correlation and LF nu and LF/HF ratio demonstrated significant negative correlation (p<0.05) with serum Mg only. Conclusion: Results of the present study revealed that low levels of serum Mg was correlated with reduced HRV in patients with RA. Moreover, low serum Mg was related to parasympathetic hypo and sympathetic hyperactivity as well as altered sympathovagal balance in RA. J Bngladesh Soc Physiol 2021;16(1): 111-117
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