Ophthalmic drug delivery is one of the most interesting and challenging endeavours facing the pharmaceutical scientists, the major problem encountered to pharmaceutical scientist is rapid precorneal elimination of the drug, resulting in poor bioavailability and therapeutic response, because of high tear fluid turn over and dynamics. Newer research in ophthalmic drug delivery system is directed towards amalgamation of several drug delivery technologies which helps to extend the contact of the vehicle at the surface of the ocular system and slows down the removal of the drug. In situ-forming gels are liquid upon instillation and undergo phase transition in the ocular cul-de-sac to form visco-elastic gel and these gels provide a response to environmental changes. In the past few years, an impressive number of novel temperature, pH, and ion induced in situ forming systems have been reported for sustained ophthalmic drug delivery. This review includes polymeric systems used in various temperatures, pH, and ion induced in situ gel formulation to achieve prolonged contact time of drugs with the cornea and increase their bioavailability.

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All the skin diseases in Ayurveda have been described under the heading of 'Kushta', which are further divided into Maha Kushtaand Kshudra Kushta. Kushta is a chronic disease that has substantial psychological and social impact on a patient's life. However the treatment options available in contemporary system of medicine are not much satisfactory. Therefore by screening of Kushtaghna dravyas from Bhavprakash Nighantu can give effective solutions for Kushta Chikitsa. The literary screening concluded that there are about 98 dravya (Herbal and Metal) are recommended as Kushtaghna, but their specific action is not defined on the basis of their Rasapanchaka. A literary review of the rasa panchaka is done to assess their probable mode of action. Samprapti of Kushta shows tridosha dushti (Vata and Kapha pradhana) and dushya are twak, lasika, shonita and mamsa predominantly, so the line of the treatment should be ushna, tikshna, Vata Kapha Shamaka, Rakta Prasadana mainly. The present paper is about to enlist the Kushtaghna herbal and metal dravyas mentioned in Bhavprakash Nighantu with their Rasa, Veerya and Vipaka, Guna and karmas for critical analysis, to assess their specific type Kushtaghna property.

Psoriasis is a dermatological disorder, which is a chronic inflammatory as well as a hyperproliferative skin disorder. Which particularly affects the extensor surfaces & scalp region. Which has a 0.09 to 11.2 % prevalence rate worldwide, Various treatments are available for this in modern medical science but they have various side effects. Ayurveda has the main aim of Prevention as well as a cure for various diseases. A 20 years old male patient was suffering from Guttate Psoriasis since one year. There are various treatment modalities and principles of Ayurveda that helps to prevent as well as cure kitibha kushtha which has a resemblance with Guttate Psoriosis. This case study intends the efficacy of Shodhana Chikitsa as well as Shamana Chikitsa in the management of Psoriasis that is Kitibha kushtha1. The Patient got highly significant results in Chief complaints i.e. Mandalotpatti, Kandu and Daha after shodhan and shaman chikitsa. (Before treatment PASSI score was 51.) Key words: Shodhana Chikitsa, Shamana Chikitsa, Guttate Psoriasis, Kitibha Kushtha,Case report.