Introduction: Methotrexate, a folic acid antagonist is used as a first line drug for the treatment of a number of malignancies and immune disorders like rheumatoid arthritis. Due to hepatoxicity its dose needs to be monitored and sometimes it has to be stopped. In the present study we intend to do a detailed histopathological investigation after methotrexate toxicity on the relatively neglected organ i.e. kidney of rat. Subjects and Methods: Albino rats were divided into four groups (1, 2, 3, and 4) of six animals each. Control group 1 was given distilled water whereas experimental groups 2, 3, and 4 were given low, therapeutic and high doses of methotrexate orally for 28 days. Results: The results showed congestion and infiltration of the glomeruli and interstitial edema and tubular degeneration which were dose dependent. Conclusion: The degenerative changes necessitate extra precautions to be taken while using drug for prolonged period. The study merits due to great social impact.
Kshara sutra has been described in most of the Ayurvedic texts not only for the treatment of Ano rectal disorders but also for all those conditions which demand gradual excision of over grown soft tissues like benign tumours, polyps, warts etc. The present study is done to rule out the role of kshar sutra in extra ano-rectal conditions to make therapy more popular. Benign tumour is a surgical condition and treatment of such condition is excision. However such treatment is painful and creates apprehension in patients. So kshar sutra is better option for treating such surgical conditions.
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