Aging appears to decrease delta6-desaturase activity in males, but in females it is uncertain. delta6- and delta5-desaturase functions were investigated in pre- and post-menopausal women who were normoglycemic or had type 2 diabetes (2 x 2 factorial, n = 37). Subjects were compared for indicators of diabetic control, estrogen levels, fatty acid profiles and indices of delta6- and delta5-desaturase activity. Diet intakes that were compared to determine whether results were a function of dietary factors known to influence desaturase activity revealed no differences (P>0.05). Post-menopausal women with type 2 diabetes had more 18:2 n6 in serum phospholipids (P<0.05) than did the pre- and post-menopausal control subjects. Fatty acid ratios of 18:3 n6/18:2 n6 indicated greater delta6-desaturase activity for women with type 2 diabetes, but differences were not found between pre- and post-menopausal groups. Significant correlation (P < 0.05) indicates an association between diabetic status and desaturase function, but function did not appear to be affected by menopausal status. In contrast to reports using male subjects, we found no evidence that desaturase function decreased in aging females, as reported for males, or increased as hypothesized in this study.
Iron content of bovine longissimus (LD) and semimembranosus muscle (SM) from steers raised at two altitudes was compared. Total iron content of fresh muscle was not different in concentrate-fed steers reared at 2145 m (HIFD) when compared to that of steers reared at 549 m (LOFD). Iron content of muscle from steers reared at 2145 m and pasture-grazed (HIGR) was lower than that from older HIFD and LOFD steers. Steaks from the HIFD and HIGR groups contained more heme iron (PcO.05) than those from LOFD steers. The nutritional significance of the differences in heme iron must be further investigated.
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