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Large-river delta-front estuaries (LDE) are important interfaces between continents and the oceans for material fluxes that have a global impact on marine biogeochemistry. In this article, we propose that more emphasis should be placed on LDE in future global climate change research. We will use some of the most anthropogenically altered LDE systems in the world, the Mississippi/Atchafalaya River and the Chinese rivers that enter the Yellow Sea (e.g., Huanghe and Changjiang) as case-studies, to posit that these systems are both ''drivers'' and ''recorders'' of natural and anthropogenic environmental change. Specifically, the processes in the LDE can influence (''drive'') the flux of particulate and dissolved materials from the continents to the global ocean that can have profound impact on issues such as coastal eutrophication and the development of hypoxic zones. LDE also record in their rapidly accumulating subaerial and subaqueous deltaic sediment deposits environmental changes such as continental-scale trends in climate and land-use in watersheds, frequency and magnitude of cyclonic storms, and sea-level change. The processes that control the transport and transformation of carbon in the active LDE and in the deltaic sediment deposit are also essential to our understanding of carbon sequestration and exchange with the world ocean-an important objective in global change research. U.S. efforts in global change science including the vital role of deltaic systems are emphasized in the North American Carbon Plan (www.carboncyclescience.gov).carbon cycling ͉ large-river-delta-front estuary ͉ land-margin interactions ͉ paleoreconstruction