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In this paper, several simple and efficient sign and error nonlinearity-based adaptive filters, which are computationally superior having multiplier free weight update loops are used for cancellation of noise in electrocardiographic (ECG) signals. The proposed implementation is suitable for applications such as biotelemetry, where large signal to noise ratios with less computational complexity are required. These schemes mostly employ simple addition, shift operations and achieve considerable speed up over the other least mean square (LMS)-based realizations. Simulation studies shows that the proposed realization gives better performance compared to existing realizations in terms of signal-to-noise ratio and computational complexity.Index Terms-Adaptive filtering, artifact, electrocardiographic (ECG), least mean square (LMS) algorithm, noise cancellation, telecardiology.