A highly efficient and eco-friendly method has been developed for the synthesis of allyl sulfones using Morita-Baylis-Hillman (MBH) adducts and thiosulfonates under mild conditions. The Cs2CO3-promoted radical sulfonylation provided a series of allyl sulfones in good to high yields with high stereoselectivities. A wide variety of MBH bromides/acetates as well as thiosulfonates were tolerated and reliable in scale-up synthesis. A plausible mechanism was also proposed to rationalize the radical sulfonylation of the experimental outcome and control experiments.
A practical, highly efficient and eco-friendly method for synthesis of multifunctional allyl thiosulfonates and allyl disulfanes is reported under mild reaction conditions.
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