Alumina was synthesized via sol-gel technique by the hydrolysis of aluminium ion controlled by urea in aqueous media. The resulting sol composed of Al(OH) 3 particles coalesced and became a transparent gel. The freshly prepared gel was heated at 280°C to obtain alumina particles. The obtained particles were found to be amorphous-alumina particles with high porosity, characterized by FTIR, XRD and S BET techniques. Electron micrograph shows that the particles are nano-sized having non-spherical shape. Comparatively higher magnitude of adsorption of cationic surfactant indicated that the surface of alumina particles is negatively charged.
Functionalized iron oxide nanoparticles (IONPs) have unique physical and chemical properties, which make them potential candidates for biomedical applications. In this study, a facile one-pot method is reported for the preparation of poly(acrylic acid) (PAA) functionalized IONPsthrough in situ free radical solution polymerization of AA and subsequent coprecipitation of Fe 3+ and Fe 2+ ions. The FTIR spectroscopic and TGA results indicated the successful formation and surface functionalization of IONPs with PAA. Electron micrographs showed that the prepared particles were of nano-sized and their shape is dependent on the concentration of PAA. pH-dependent variation of average hydrodynamic diameter confirmed the pH-responsivity of PAA-functionalized IONPs. Magnetic measurement suggested that the PAA functionalized IONPs were strongly paramagnetic (53.0 emug −1 ). Fenton-like catalytic generation is carried out to measure toxicity associated with the nanoparticles. The suppression ability for reactive oxygen species (ROS) generation associated with PAA-functionalized IONPs was studied via methylene blue degradation assay to address their toxicity profile. PAA-functionalized IONPs exhibited better suppression ability than that of the bare IONPs. The adsorption behavior of trypsin was also studied at different pH levels and a maximum adsorption is occurred on PAA-functionalized IONPs at pH 5.0. Catalytic behavior study confirmed higher activity of trypsin immobilized on PAA-functionalized IONPs than that of the reference IONPs. Therefore, the functionalized IONPs can be of high interest for magnetically recyclable biocatalyst carrier.
Nowadays, development of functional polymer-coated inorganic composite particles is one of the important topics of investigation for biomedical applications. Although, several studies have tried to design hybrid nanocomposites, this study...
This study examined the encapsulation of submicron-sized silica particles by stimuli-responsive copolymer shell layer. Silica/poly(2-dimethylaminoethyl methacrylate-N-isopropylacrylamide-ethyleneglycol dimethacrylate), abbreviated as silica/P(DM-NIPAM-EGDM) core-shell composite polymer particles, were prepared by the seeded copolymerization of DM, NIPAM and EGDM in the presence of silica particles. The morphology and size distribution were analyzed by scanning electron microscopy. The surface composition showed silica particles covered with a copolymer shell layer consisting of P(DM-NIPAM-EGDM). The temperature and pH dependent adsorption behavior of the low molecular weight surfactants and biomolecules on the silica/P(DM-NIPAM-EGDM) composite polymer particles indicated a stimuli-responsive phase transition. The activity of the adsorbed trypsin (TR) on the composite particles remained high compared to the free TR and adsorbed TR on silica particles.
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