Background: Pemphigus vulgaris is an autoimmune, potentially fatal vesiculobullous disease of skin and mucous membranes. The clinical profile and epidemiologic characteristics varies in patients to patients and in different communities. The aim of this study was to evaluate the clinical and epidemiological features, morbidity and mortality of pemphigus vulgaris and to compare that with other studies of different communities. Methods: It was an observational study, conducted on 24 hospital admitted cases of pemphigus vulgaris at the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The duration of the study was from November 2018 to February 2020. Patients who were confirmed as pemphigus vulgaris both histopathologically and direct immunofluroscent test were included for that study. Findings: The mean age (SD) of the patients was 47(15.5) years. Male outnumbered female in that study and male to female ratio was 1.4: 1. The mean (SD) duration of disease was 15(18.6) months. Pain (70.8) was the commonest symptoms. Trunk (92%) was the commonest cutaneous site of involvement followed by oral mucosa (71%). Oral prednisone was the mainstay of treatment and it was given to 24 (100%) of the patients. The immunosuppressant adjuvant was given in 79% cases. Azathioprine (62.5%) was the commonest of them. To avoid osteoporosis calcium supplement with or without vitamin D and bisphosphonate was given in 92% cases. The mean (SD) hospital stay was 5.4(3.3) weeks. Bacterial infection was the commonest complication and it was found in 2 patients. The mortality rate of that study was 4.16%. Conclusion: pemphigus vulgaris is a dermatological emergency and the maximum patients need hospitalization for proper care. Hospital acquired infections are the common complication and that may leads to septicemia and death. To decrease the mortality of pemphigus vulgaris the care givers have to be more watchful about the potential of infections. J Dhaka Med Coll. 2021; 29(1): 24-30
Psoriasis is a common chronic inflammatory disease of skin and multiple organs of body. The exact etiology of psoriasis is not yet certain. It is assumed that trace elements may have some role in pathogenesis of psoriasis. They can act as co-enzymes for metabolism and can act as antioxidants against free radicals. Therefore they can participate in epidermal proliferation and inflammatory process of psoriasis. This study aimed to evaluate the relation between psoriasis and trace elements namely zinc and copper. This study was conducted on 40 diagnosed cases of psoriasis and 40 non psoriatic individuals in the department of Dermatology and Venereology in Bangabandhu Sheikh Mujib Medical University, Dhaka. Biochemical analyses of serum copper and zinc were analyzed and compared statistically with cases and healthy controls. Serum zinc level was significantly lower and serum copper level was significantly higher in patient with psoriasis compared to control (p= < 0.001). Individuals with moderate to severe psoriasis had significantly lower zinc levels and significantly higher copper levels than patients with mild psoriasis, according to Psoriasis area and Severity Index Score (p= < 0.05). Correction of serum zinc and copper level could be beneficial for psoriasis patients. Bangladesh Med J. 2021 May; 50(2) : 28-31
A cross-sectional study was conducted in the Department of Biochemistry and Molecular Biology of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh, between July 2016 and June 2017, to evaluate serum zinc level and its relationship with glycemic control in type 1 diabetic children. A total of 160 participants (all aged between 1 and 18 years) were selected from the outpatient department (OPD) of BIRDEM General Hospital-2, Dhaka – 80 type 1 diabetic children as cases and 80 apparently healthy children as controls. We measured anthropometric parameters all study subjects. Serum zinc level was assessed using colorimetric method. Fasting plasma glucose level was estimated using enzymatic glucose-oxidase method. Glycemic control was evaluated through estimation of HbA1c using a high-performance liquid chromatographic method. The mean serum zinc levels were significantly lower in patient with type 1 DM compared to control (72.5±16.5 vs. 82.4±13.3 μg/dl; P<0.001). Lower levels of zinc were found in subjects with poor glycemic control compared to good glycemic control (62.8±14.6 vs. 78.8±14.6 μg/dl; P<0.001). Moreover, serum zinc levels were significantly lower in patients who have duration of diabetes mellitus for 5 years or more (P<0.05). To summarize, serum zinc level is lower in type 1 diabetic children in comparison to its healthy counterpart and this lower zinc level is strongly associated with poor glycemic control which may potentially contribute to the early development of diabetic complications in children. CBMJ 2022 July: vol. 11 no. 02 P: 80-85
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