Parkinson’s disease (PD) is a neurodegenerative disorder responsible for shaking, rigidity, and trouble in walking and patients’ coordination ability and physical stability deteriorate day by day. Bipolar disorder (BD) is a psychiatric disorder which is the reason behind extreme shiftiness in mood, and frequent mood inversion may reach too high called mania. People with BD have a greater chance of developing PD during the follow-up period. A lot of work has been done to understand the key factors for developing these 2 diseases. But the molecular functionalities that trigger the development of PD in people with BD are not clear yet. In our study, we are intended to identify the molecular biomarkers and pathways shared between BD and PD. We have investigated the RNA-Seq gene expression data sets of PD and BD. A total of 45 common unique genes (32 up-regulated and 13 down-regulated) abnormally expressed in both PD and BD were identified by applying statistical methods on the GEO data sets. Gene ontology (GO) and BioCarta, KEGG, and Reactome pathways analysis of these 45 common dysregulated genes identified numerous altered molecular pathways such as mineral absorption, Epstein-Barr virus infection, HTLV-I infection, antigen processing, and presentation. Analysis of protein-protein interactions revealed 9 significant hub-proteins, namely RPL21, RPL34, CKS2, B2M, TNFRSF10A, DTX2, HLA-B, ATP2A3, and TAPBP. Significant transcription factors (IRF8, SPI1, RUNX1, and FOXA1) and posttranscriptional regulator microRNAs (hsa-miR-491-3p and hsa-miR-1246) are also found by analyzing gene-transcription factors and gene-miRNAs interactions, respectively. Protein-drug interaction analysis revealed hub-protein B2M’s interaction with molecular drug candidates like N-formylmethionine, 3-indolebutyric acid, and doxycycline. Finally, a link between pathological processes of PD and BD is identified at transcriptional level. This study may help us to predict the development of PD among the people suffering from BD and gives some clue to understand significant pathological mechanisms.
Aims: Iodine deficiency is one of the most common micronutrient deficiencies in Bangladesh. To combat iodine deficiency disorders, universal salt iodization is mandatory in Bangladesh. The aim of our study was to determine the iodine content of both packaged and open edible table salts sold at the retailer level in different areas of Bangladesh. Study Design: The study is an experimental cross-sectional study. Place and Duration of Study: The present study was conducted in the food analysis laboratory of Department of Food Technology and Nutrition Science, Noakhali Science and Technology University from March 2019 to June 2019. A total of 90 salt samples were collected from ten retailers selected based on convenience sampling from two districts: Dhaka and Noakhali. Among the samples, 45 were packaged salts from Fifteen different brands and the rest of the 45 samples were non brand open salt. Methodology: The iodine content of iodized salt samples was determined by the iodometric titration method. Results: The mean iodine content of both types of salts is 17.801±1.973 ppm. The mean iodine contents of packaged salts and open salts are 30.691±2.679 ppm and 4.912±1.008 ppm, respectively. Only 42% of the total salt samples are adequately iodized (>20 ppm). 75% of packaged salt samples are adequately iodized and only 8% of open salt samples are adequately iodized. Conclusion: As iodine content in open table salts doesn’t meet the criteria set by the government, the sale of open salt for human consumption should be stopped.
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