The purpose of this study was to determine the effect of the superoxide dismutase mimic compound “tempol” on liver and renal damage in Long Evans male rats administered with carbon tetrachloride (CCl4). Methods: The antioxidant enzyme activity and oxidative stress parameters were investigated in the liver, kidney, and plasma tissues. Histological examination of the liver and kidney sections affirmed inflammatory cell infiltration, collagen deposition, and iron deposition. RT-PCR was also employed to evaluate the expression of oxidative stress and inflammatory genes. Results: The CCl4-administered rats exhibited increased plasma activities of ALT, AST, and ALP compared to the control rats. The tempol treatment in the CCl4-administered rats significantly lowered ALT, AST, and ALP enzyme activities compared to the CCl4 group. Oxidative stress parameters, such as the MDA, NO, and APOP levels in various tissues of the CCl4-administered rats, showed increased concentrations, whereas tempol significantly lowered the level of oxidative stress. Moreover, CCl4 administration decreased the antioxidant enzyme activities, which were further significantly restored by the tempol treatment. The control rats that underwent treatment with tempol did not present with any abnormality or toxicity. Furthermore, the tempol treatment in the CCl4-administered rats increased Nrf-2-HO-1-mediated gene expression and enhanced related antioxidant enzyme gene expressions. The tempol treatment in the CCl4-administered rats also decreased anti-inflammatory gene expressions in the liver. In histological sections of the liver, CCl4 increased inflammatory cell infiltration, collagen deposition, and iron deposition, which were reduced significantly due to the tempol treatment. Conclusion: The results of this investigation revealed that tempol could protect against liver and kidney damage in CCl4-administered rats by modulating antioxidant gene expressions and restoring antioxidant defense mechanisms.
-This paper aims to improve the performance of conventional direct torque control (DTC) drives proposed by Takahashi by extending the idea for 5-level inverter. Hybrid cascaded H-bridge topology is used to achieve inverter voltage vector composed of 5-level of voltage. Although DTC is very popular for its simplicity but it suffers from some disadvantages like-high torque ripple and uncontrollable switching frequency. To compensate these shortcomings conventional DTC strategy is modified for five levels voltage source inverter (VSI). Multilevel hysteresis controller for both flux and torque is used. Optimal voltage vector selection from precise lookup table utilizing 12 sector, 9 torque level and 4 flux level is proposed to improve DTC performance. These voltage references are produced utilizing a hybrid cascaded H-bridge multilevel inverter, where inverter each phase can be realized using multiple dc source. Fuel cells, car batteries or ultra-capacitor are normally the choice of required dc source. Simulation results shows that the DTC drive performance is considerably improved in terms of lower torque and flux ripple and less THD. These have been experimentally evaluated and compared with the basic DTC developed by Takahashi.
Soliton in fiber optic is a good solution to achieve the benefits of optical fiber without many of its limitations like the use of more repeaters or amplifiers in case of long haul communication. This work considered three particular long haul systems (Three segments of SEA-ME-WE 4 sub marine cable Networks) and shown the difference between the signal response in case of fiber optics with Gaussian pulse and with Soliton pulse. The parameters considered for this purpose are-pulse broadening ratio, phase displacement, attenuation and number of amplifiers used. By simulation, both the pulses were transmitted through optical amplifiers and analyzed their performances to show that the performances with Soliton pulse are better than the performances with Gaussian pulse over the long haul fiber optics communication.
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