The clinical efficacy and safety of preanaesthetics and induction agents were examined and compared on the basis of clinical and serum biochemical indicators in rabbits. Eight apparently healthy rabbits (3.0-3.5kg) of either sex were arbitrarily allocated into two groups: Group DK (diazepam-ketamine) and Group DFK (diazepam-fentanyl- ketamine). Rabbits were received intramuscular diazepam (5mg/kg), fentanyl (0.02 mg/kg) and ketamine (35 mg/kg). Data on clinical parameters (rectal temperature, heart rate and respiratory rate) and reflexes (righting reflex, palpebral reflex and pedal reflex) were evaluated before and at 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100 minutes after injection of anaesthetics. Blood samples were aspirated prior to anaesthesia and 30 minutes following induction. Serum Albumin, Globulin, Cholesterol, Triglyceride, Total Protein, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Creatinine, Calcium, Phosphorus, Sodium, Potassium and Chlorine were evaluated through semiautomatic biochemistry analyzer. In this study, no significant changes in rectal temperature were observed in the animals of group DK during anaesthesia. During anaesthetic cascade, heart rates and respiration rates in both the groups were reduced significantly (P< 0.05). In DFK-injected rabbits, the return of righting and palpebral reflexes were delayed. The DFK groups had considerably (P< 0.05) longer surgical anaesthesia than the DK groups. In terms of serum biochemistry, DK-treated rabbits had significantly lower total protein, globulin, creatinine, HDL, sodium, and potassium concentrations (P< 0.05). Total protein, cholesterol, HDL, and potassium levels decreased significantly (P
Clinical and serum biochemical markers were utilized to assess the clinical efficacy of routinely used preanaesthetics and induction agents in rabbits. Eight healthy rabbits (3.0-3.5kg) of either sex were randomly assigned to one of two groups: XK (Xylazine-ketamine) or XFK (Xylazine–fentanyl–ketamine). Intramuscular injections of xylazine (5 mg/kg), ketamine (35 mg/kg), and fentanyl (0.02 mg/kg) were given to rabbits. Clinical parameters (rectal temperature, heart rate, and respiratory rate), as well as reflexes (righting reflex, palpebral reflex, and pedal reflex), were measured before and after anaesthetic injection at 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100 minutes. Blood samples were also taken before anaesthesia and 30 minutes following induction. An autoanalyzer was used to examine serum biochemical parameters. In the XFK group, we observed that rectal temperature increased considerably (P
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.