We review the recent development of Conservation Agriculture (CA) for rice-based smallholder farms in the Eastern Gangetic Plain (EGP) and the underpinning research on agronomy, weed control, soil properties and greenhouse gas emissions being tested to accelerate its adoption in Bangladesh. The studies are based mostly on minimum soil disturbance planting in strip planting (SP) mode, using the Versatile Multi-crop Planter (VMP), powered by a two-wheel tractor (2WT). One-pass SP with the VMP decreased fuel costs for crop establishment by up to 85% and labour requirements by up to 50%. We developed strip-based non-puddled rice (Oryza sativa) transplanting (NPT) in minimally-disturbed soil and found that rice grain yield increased (by up to 12%) in longer-term practice of CA. On farms, 75% of NPT crops increased gross margin. For non-rice crops, relative yield increases ranged from 28% for lentil (Lens culinaris) to 6% for wheat (Triticum aestivum) on farms that adopted CA planting. Equivalent profit increases were from 47% for lentil to 560% for mustard (Brassica juncea). Moreover, VMP and CA adopting farms saved 34% of labour costs and lowered total cost by up to 10% for production of lentil, mustard, maize (Zea mays) and wheat. Effective weed control was obtained from the use of a range of pre-emergent and post-emergence herbicides and retention of increased crop residue. In summary, a substantial body of research has demonstrated the benefits of CA and mechanized planting for cost savings, yield increases in many cases, increased profit in most cases and substantial labour saving. Improvement in soil quality has been demonstrated in long-term experiments together with reduced greenhouse gas emissions.

No abstract

Aducanumab is a novel disease-modifying anti-amyloid-beta (Aβ) human monoclonal antibody specifically targeted to the pathophysiology of Alzheimer's disease (AD). It was granted for treating AD in June 2021 by the United States Food and Drug Administration. We systematically analyzed available trials to evaluate the efficacy and safety of aducanumab treating AD. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. We conducted an extensive literature search using the electronic databases MEDLINE through PubMed, EMBASE, Cochrane, Web of Science, and Scopus for suitable studies on aducanumab. We considered human clinical trials of aducanumab, assessing its efficacy and adverse effects in treating AD, excluding any experimental animal studies. We included three randomised controlled trials. Studies reported that aducanumab reduced brain amyloid-beta plaques in a time-and dose-dependent manner (dose-response, P < 0.05) and a slowed decline in cognition (22% reduction) in the high-dose treated group, difference of À0.39 versus placebo in Clinical Dementia Rating Scale Sum Boxes (95% CI, À0.69 to À0.09; P = 0.012) along with a reduced amyloid positron emission tomography standard uptake value ratio score (P < 0.001) and plasma p181-tau (phosphorylated tau) level. Amyloid-related imaging abnormality was reported as a serious adverse event and was profound in high-dose treated group (425/1029 in 10 mg/kg). Aducanumab has been reported to affect two main pathophysiologic hallmarks (Aβ and tau) of AD. We suggest future studies addressing aducanumab's efficacy and safety to confirm that the benefit of this drug outweighs the risk.

Reasonable use of agricultural machinery has an extraordinary potential for poverty alleviation by increasing land and labor productivity in Thailand, Vietnam, and even in Bangladesh. This study was conducted under a program entitled “Agriculture Mechanization, Agro-Processing, Value addition and Export Market Development in Thailand and Vietnam from 1–14 November, 20I9” from the Ministry of Agriculture, Bangladesh. In all three distinct nations, farming activities represent a significant area of activity and remains the biggest wellspring of agricultural business. About 10.5% of Thailand’s, 21.5% of Vietnam’s, and 14.23% of Bangladesh’s GDP come from agriculture. For sustainable development, it is essential to modernize agriculture through the mechanization of its operations, which is therefore inevitable in the studied countries. Thailand’s government started mechanization in 1891 with the import of steam-powered tractor and rotary hoes. Since then the country has witnessed several milestones in the course of mechanization development. The focal plain agro-ecological zone of the state is the maximum and almost fully modernized area. As of now, there are two methods of practicing farming apparatus use: as a proprietor and/or through custom renting provision which coincides with Vietnam and Bangladesh. Historically, mechanization patterns in Vietnam can been described by tillage machinery with associated implement equipment use preceding 1975. This was non-linear, followed by a decreasing trend during the 80s prior to recovery during the 90s, with significant disparities in implementation status across the areas. In 2018, the number of tillage implements and harvesters was boosted about 1.6 and 25.6 times, respectively compared with 2006. The percentage of machinery use in soil tillage operation is 80% of the whole territory of cultivable land in Vietnam, compared to about 90% in Bangladesh and 100% in Thailand. Mechanization in Bangladesh started before independence with the importation of 2-wheel tractors and irrigation pumps in the last part of the 1960s as part of ‘Green Revolution’ activities. To continue this momentum, the Bangladesh Government permitted the continuation of agricultural machinery importation after later autonomy. Machinery use in different agricultural activities has increased in recent years in the areas of irrigation, land preparation, intercultural operation, and threshing. Though its degree of advancement is by and large still quite low contrasted with other South Asian nations, it is noticeable that the most recent two decades, the pace of mechanization has increased rapidly with the increase of mechanical power use in farm activities. The use of farm machinery in rice cultivation has been the most amazing when contrasted with different crops in these three nations. A clear comparison has been given in the paper, which aims to help researchers and policymakers take necessary measures.

Rice seedling for mechanical transplanting must fulfill the prerequisites of guideline seedling block with uniform density of seedlings and between bending pulls for rolling. The present study was carried out at the Farm Power and Machinery Department, Sylhet Agricultural University, Sylhet during Boro season/2018-19 with the objective to assess the impact of organic substance on agronomic attributes of mat type rice seedling. The seedling was raised on plastic rigid tray utilizing sandy clay loam (SCL) and sandy clay (SC) soil blending with the organic fertilizer of cow-dung (CD), rice bran (RB), rice husk (RH) and tea wastage (TW) at the rate of 0.0, 5, 10, 15 and 20%, respectively. Averaged across the rate of soil mixture, 5 to 15% of CD and RB with the both types of soil gave higher seedling height, leaf length and stem length while 20% of CD and TW also showed better result for number of leaves and stem thickness. Considering all parameters, 15 to 20% rice husk and tea wastage mixed with the sandy clay loam soil and 10 to 15% with the sandy loam soil gave good result. Be that as it may, seedling quality differed among the natural composts with the two kinds of soil more or less like CD > RB > TW > RH. Water requirement in the SC soil was more compared to SCL soil. It was observed that crack was formed on the sandy clay soil in tray. For both types of soil, the density of seeds in the mat at the rate of 6-7 seeds cm-2 was found at 80% of soil mixture along with rice bran. The findings of the study could be promoted widely in farmer’s field to raise better quality of mat type seedling for better performance of the mechanical rice transplanter which ultimately leads to getting better rice yield.