Wound healing, a common clinical entity contemporary to human beings, has been recognized to be influenced by several factors such as nutrients like vit-C, zinc, and hormones like GH, insulin, etc. Products of traditionally used plants such as Bryophyllum pinnatum [1] and Moringa oleifera [2] have also been reported to promote healing in experimental animals, probably by virtue of their antimicrobial activity. Because it is well known that infection interferes with healing, antimicrobials are expected to suppress infection and promote healing process only in infected wounds. Antimicrobials are routinely administered pre-and post-surgically and metronidazole, a commonly used antiprotozoal for surgical chemoprophylaxis against anaerobes, is likely to influence the surgical outcome. However, metronidazole (MTZ) has been reported to delay the healing process in dead space wounds [3] and reduce the breaking strength of facial wounds. [4] Recently, MTZ has been reported to possess a potent anti-oxidant property that augments healing process in burns. [5] Similarly, tinidazole (TNZ) has also been reported to suppress healing of dead space wounds, [3] whereas fluconazole (FLZ), a related antifungal azole, has been shown to enhance epithelization. [13] There are no reports on the influence of ketoconazole (KCZ) on wound healing, an antifungal related to fluconazole.
The traditional teaching in the management of rectovestibular fistula involves corrective surgery, either in single or multiple stages. Usually, female children operated for the same are advised cesarean section during childbirth to prevent damage to the neoanus. Herein, we report a story of a 68-year-old woman with untreated rectovestibular fistula and has given birth to five children without any sequalae.
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