Markedly more stable than the natural product, di‐fluoroprostacyclin 1 inhibits ADP‐induced human platelet aggregation better than any other known prostacyclin derivative. Key steps in the synthesis of 1 are fluorination of the Corey lactone with (Ph‐SO2)2NF in the presence of MgBr2 and subsequent Wittig reaction to attach the α side chain.
In this study, we clarified the characteristic features of skin induced by incontinence. Our results indicate that these parameters are adequate not only to evaluate the characteristic skin features of bedridden incontinent subjects but also to develop new diapers to avoid the diaper dermatitis caused by incontinence.
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