Background Liver fibrosis proceeds to portal hypertension, and portal hypertensive gastropathy is considered its main complication. Olive oil is associated with human health benefits. Aim To study the effect of olive oil on the stomach after induction of liver fibrosis. Materials and methods A total of 50 healthy adult male albino rats were randomly divided into two groups, including group I (control group) and group II (experimental group), which were subdivided into four subgroups: olive oil-treated subgroup IIa received 5 ml/kg body weight olive oil daily by an orogastric tube for 4 weeks, subgroup IIb received 0.1 ml/100 g body weight carbon tetrachloride (CCL4) by intraperitoneal injection twice per week for 4 weeks, subgroup IIc received both olive oil and CCL4 at the same dose of subgroups IIa and IIb for the same period, and subgroup IId received CCL4 for 4 weeks and then olive oil was given alone for another 4 weeks as the same dose in subgroups IIa and IIb. Stomach specimens were processed for histological and immunohistochemical study. Results Subgroup IIb showed disorganized and atrophic gastric glands with severe interstitial hemorrhage and diffuse inflammatory infiltrates. The parietal cells had vacuolated cytoplasm with irregular nuclei, and others had karyolitic nuclei with vacuolization of the cytoplasm of some chief cells. Subgroup IIc showed significant improvement, and subgroup IId showed nonsignificant improvement. Conclusion The use of olive oil partially improved the histological changes in the stomach as a result of liver fibrosis.
Background: Ageing refers to a multidimensional process of physical, psychological, and social change. Fructose is widely used in foods and beverages because of its high relative sweetness. Soybean oil is one of the most widely consumed cooking oils; also, coconut is a part of the daily diets of many people. Aim of Study:The aim of this study was to demonstrate the histological and immunohistochemical changes that may be induced by aging, high-fructose dietsand high-fat dietsin pancreatic Islets of Langerhans in albino rats.Material and Methods: This study was conducted on 40 albino rats, divided into 4 groups. Group I or Control groupreceived normal diet and were sacrificed by age of 2 months. Group II (aging group) that received a normal diet. Group III: That received normal diet in addition to fructose for one month. Group IV: That received normal diet in addition tococonut and soya bean oil dailyfor 1 month. Animals in group II, III and IV were sacrificed at the age of 12 months. After being sacrificed, their pancreases were extracted and prepared for light microscopic, electron microscopic and immunohistochemical studies.Results: It was found that aging was associated with degenerative changes in the Islet cells of Langerhans of the pancreas in albino rats and these changes were aggravated by concomitant consumption of high fructose or high fat diets. Conclusion:Diets rich in fructose and/or fats may exacerbate aging-induced degenerative changes in the pancreatic Islet of Langerhans. Accordingly, it is recommended to keep consumption of fructose and fats at a reasonable level.
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