A novel simple green synthesis route was applied to produce copper oxide (CuO) nanoparticles (NPs) and CuO nanograins (NGs) by using cupric chloride dihydrated as copper salt precursor, curcumin (a natural and non-toxic food spice) as conjugated agent with or without cetyl trimethylammonium bromide acting as a stabilizing agent at extreme basic condition. Synthesis of this curcumin conjugated CuO nanoparticles was optimized by studying effect of several parameters starting with copper salt precursor, curcumin concentration, pH and temperature. Scanning electron microscopy coupled to Energy Dispersive X-ray Analyzer, thermogravimetirc analysis, X-ray diffraction, UV-visible spectroscopy, fluorescence spectroscopy and zeta potential were used to characterize the resulted CuO NPs/NGs. In this work, the synthesized copper oxide nanograins were found to be efficient nano-catalysts for the reduction of methylene blue and it was found that nanograin has better catalytic activity compared to spherical shape nanoparticles, emphasizing shape of the CuO particles is crucial for its nanocatalytic activity.
In this manuscript, the aim is to functionalize CuO nanoparticles with the supramolecular host molecule, in this case curcubit[6]uril to have a host guest interaction between the CuO nanoparticles and probe (guest) molecules. Acridine Orange (AO) is applied as a guest molecule. Acridine orange binds with curcubit[6]uril via its carbonyl rims. In the presence of curcubit[6]uril conjugated CuO nanoparticles, the fluorescence intensity of AO is quenched by the CuO NPs through fluorescence resonance energy transfer phenomenon. However, dopamine adsorbs on the surface of CuO nanoparticles by getting incorporated into CB[6] host molecules and kicks out AO from curcubit[6]uril pocket, thus, discouraging fluorescence resonance energy transfer phenomenon and thus enhancing fluorescence intensity of AO by a factor of 3. This fluorescence recovery has been utilized to design a new detection system for dopamine. The assay, measured at fluorescence excitation and emission wavelengths of 480 nm and 520 nm respectively, works in the 0-40 μM concentration range of dopamine with 40 nM limit of detection. This method is not interfered by ascorbic acid, uric acid, glucose, tryptophan and acetaminophen. The proposed method provides a good recovery from synthetic samples and shows good stability.
This work reportsnon-cross-linking of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) stabilized copper oxide nanoparticles for the detection of mercury ions through the resonance Rayleigh scattering method.
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