There is evidence that differentiation of self (DoS) contributes to the regulation of emotions at a young age, resulting in reduced anxiety and improved mental well-being. However, there is little evidence of the relationships between these four dimensions (DoS, self-regulation, anxiety, and mental well-being), or of the potential mediating role of self-regulation and anxiety. Our primary goal was therefore to consider the links between DoS, self-regulation, anxiety, and mental well-being. It was hypothesized that DoS (emotional reactivity, I-position, emotional cutoff, fusion with others) will be positively associated with mental well-being through the mediation of self-regulation (promotion-focused, prevention-focused) and anxiety. The study included 460 participants with a mean age of 41.18 (SD = 14.97, range = 19–60). Of them, 224 (48.7%) were women. Participants filled out four questionnaires: the Differentiation of Self Inventory–Revised, General Regulatory Focus Measure, the anxiety scale from DASS–21, and the Warwick–Edinburgh Mental Well-being Scale. The findings showed that emotional cutoff positively predicted prevention and anxiety, but did not predict promotion. In addition, promotion positively predicted mental well-being. Finally, promotion mediated the relationship between I-position and mental well-being. The results indicate that well-differentiated individuals function optimally and enjoy good quality of life.
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