Background and Objective: Sepsis is a potentially life-threatening disorder in ICU. The worst complication is organ dysfunction and mortality. Procalcitonin (PCT) and C-Reactive Protein (CRP) had been proposed as biomarker and predictor for diagnosis, prognosis, and patient deterioration in sepsis and septic shock patients. To know whether PCT and CRP can be used as a predictor of organ dysfunction and outcome in sepsis and septic shock patients in ICU.Materials and Methods: Data were cohort retrospectively analyzed in 35 sepsis (45.5%) and 42 septic shock patients (54.5%) admitted to ICU Dr. Wahidin Sudirohusodo General Hospital (January 2014 -December 2015). Data were analyzed using Chi-Square test, Pearson Correlation, and Spearman-Rho Correlation test.Results: Total of 77 patients met the inclusion criteria. Cut-off point in predicting organ dysfunction in sepsis and septic shock was significantly higher in PCT (45.7ng/mL) with 76.6% sensitivity and 70.0% specificity, while CRP was 145.75 mg/mL with 70.2% sensitivity and 56.7% specificity. There was a positive correlation of PCT (0.492 [p=0.000]) and CRP (0.336 [p=0.003]) to organ dysfunction reflected on SOFA score using the Pearson Correlation test (p<0.01 statistically significant). Based on Spearman-Rho Correlation test, correlation of PCT (0.191 [p=0.097]) and CRP (0.110 [p=0.340]) to outcome in day-7 was positive but not statistically significant (p≥0.01). While in day-28, there was positive correlation 0.553 (p=0.001) for PCT, 0.460 (p=0.006) for CRP, and statistically significant (p<0.01).Conclusions: Procalcitonin and CRP can be used as a predictor of organ dysfunction and outcome in sepsis and septic shock patients.Keywords: CRP, procalcitonin, sepsis, outcome, organ dysfunction, septic shock Significant StatementSepsis is a major cause of mortality and morbidity in critically ill patients. Procalcitonin is a prohormone of calcitonin contained in the human body. In sepsis, increased levels of procalcitonin in the blood has a significant value that can be used as a biomarker of sepsis. Compared with other sepsis biomarkers such as CRP, procalcitonin levels are more sensitive and the most rapid rise after exposure to the infection. In another study, the level of invasion of microorganisms in sepsis provides rhythm correlation with increased levels of procalcitonin blood. Provision of appropriate antibiotic therapy will reduce levels of procalcitonin in sepsis, but antibiotics are not appropriate to raise the levels. The high rate of mortality in sepsis indicates the need for action and research to reduce this mortality, one of them with early diagnosis and management of sepsis. In Indonesia research on the use of the parameters of procalcitonin and CRP in patients with sepsis is still very limited, in Makassar has never done research on the parameters of procalcitonin and CRP in patients with sepsis, therefore, this study aims to determine whether the PCT and CRP can be used as a predictor of organ dysfunction and outcomes of patients with s...
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