In Reply We are grateful to Mahmood and Leung for their interest in our article. 1 They argue that there are more efficient ways to test for the MT-RNR1 m.1555A>G variant than the rapid point-of-care test (POCT) used in our study. They correctly state that m.1555A>G is subject to mitochondrial inheritance, and therefore knowing whether the mother was a carrier prior to delivery would negate the need for a rapid POCT. This biological assessment is sound, and testing every expectant mother for the variant would theoretically remove the need for rapid testing. However, this is neither cost-effective nor practicable. 2 The authors outline several mechanisms by which mothers might be preemptively tested for m.1555A>G. The first is that mothers could be tested when they meet certain criteria, Letters 828
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