Recurrent cervical cancer has a grim prognosis with 5-year survival <5%. Current treatment options are limited; standards of care such as palliative chemotherapy and surgical resection often provide a small survival advantage. To date, only one targeted agent has FDA approval for the treatment of recurrent cervical cancer. We present the case of a novel application of olaparib, a poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitor, as single-agent therapy for recurrent metastatic clear cell cervical cancer in a patient with a somatic BRCA2 mutation. The patient had excellent response to therapy with stable disease without evidence of progression until 14 months of therapy, at which time she was switched to an alternative regimen.
Orthopaedic injuries warranting trauma activation in pregnant patients are associated with increased risks of preterm birth, placental abruption, and infant and maternal death.» Physiological changes associated with pregnancy can mask the severity of orthopaedic injury sustained during trauma. Providers must perform all appropriate imaging studies associated with the mechanism of injury and perform a careful clinical examination in order to avoid missing injuries.» Pregnancy is a hypercoagulable state, and adequate prophylaxis for blood clots includes low-dose heparin as well as mechanical prophylaxis. Additionally, patients who have sustained orthopaedic trauma must be assessed frequently for thrombophlebitis.Disclosure: The authors indicated that no external funding was received for any aspect of this work. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSREV/A519).
The mean score overall for the entire TUQ was 4.3/5. Participants preferred telemedicine for follow-up visits rather than for initial visits (81% vs. 33%; P,.01).CONCLUSION: Underserved women utilizing telemedicine for gynecologic care reported largely positive experiences with improved access to health care, cost, and time savings over inperson visits. However, a higher preference for utilization was found for follow-up visits, providing an opportunity to further improve quality and access.
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