The Picacho Mountains (SE Arizona, USA) are composed of a variety of Paleogene, Late Cretaceous, and Proterozoic granite and gneisses that were deformed and exhumed along the gently south to southwest dipping detachment shear zone associated with the Picacho metamorphic core complex. The detachment shear zone is divided into three sections that record a progressive deformation gradient, from protomylonites to ultramylonites, and breccia. New thermochronological data from mylonite across the footwall of the detachment shear zone associated with the Picacho metamorphic core complex suggest that the footwall was exhumed through about ~300°C between 22 and 18 Ma by progressive incisement of the footwall of the detachment shear zone. Combined geochronological and oxygen and hydrogen stable isotope data of metamorphic silicate minerals reveal that mylonite recrystallization occurred in the presence of a deep‐seated metamorphic/magmatic fluid, and experienced a late stage meteoric overprint during the development and exhumation of the detachment shear zone. Quartz‐biotite and quartz‐hornblende geothermometry from the base to the top of the detachment shear zone yield equilibrium temperatures ranging from 630 to 415°C, respectively. This temperature trend is attributed to an insulating effect caused by rapid slip and juxtaposition of cool hanging wall on top of a hot footwall. It is suggested that rapid cooling of the top of the detachment shear zone caused strain to migrate toward lower structural level by incisement of the footwall of the shear zone. Progressive strain front migration into the ductile footwall produced hydromechanical anisotropies parallel to the detachment shear zone, effectively saturating the footwall with magmatic/metamorphic fluids and preventing downward flow of meteoric fluids. The combined microstructural, geochronological, and stable isotope results presented in this study provide insight on the dynamic feedback between deformation and fluid flow during the evolution of a detachment shear zone.