Maximiliano Ibarra scite author profile

The role of a 1D -adrenoceptors in the vasculature of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY), of dierent ages was assessed in pithed rats by the use of the selective a 1D -adrenoceptor antagonist BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-8-azaspiro [4.5]decane-7,9-dione dihydrochloride). BMY 7378 displaced the pressor eect of phenylephrine in young pre-hypertensive pithed SHR rats, but produced no eect in young WKY rats (dose ratio of 3.4 and 1.6, respectively), while in adult rats BMY 7378 produced a greater shift in the phenylephrine response curve than in younger animals (dose ratio of 3.2 and 6.2 in WKY and SHR, respectively). The presence of a 1D -adrenoceptors in the vasculature of pre-hypertensive rats, suggests its role in the pathogenesis/maintenance of increased blood pressure.

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Effects of aging and hypertension on learning, memory, and activity in rats

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Castillo²,

Ibarra

et al. 1996

Physiology & Behavior

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Effects of nimodipine on learning in normotensive and spontaneously hypertensive rats

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Terrón

Ibarra

et al. 1997

Behavioural Brain Research

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