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In patients with acute myelogenous leukemia, published guidelines and treatment recommendations are usually the basis for starting the work-up process for allogeneic transplant. However, only consistent recommendations would allow a standardized clinical practice. We conducted a comprehensive systematic literature search to identify and evaluate the best available evidence from controlled clinical trials. In addition, recommendations given by leading organizations in the USA and Europe were analyzed. The following aspects were selected for systematic comparison: factors for risk assessment and categorization, role of type of donor, significance of allogeneic transplant in first or second complete remission and in relapse/progressive disease; and role of reduced intensity conditioning regimens. In conclusion, the recommendations for the use of allogeneic transplant given by the literature and by published guidelines are inconsistent and will need clarification.

Morbidity and mortality (M&M) conferences serve as a forum for the discussion of adverse events and errors in the treatment of patients. In the United States M&M conferences are an established part of medical training programs. While being state of the art in specialities like surgery and anesthesiology, they were established later on in internal medicine. To date, no reports have been published on M&M conferences in departments of internal medicine in Germany. Since August 2010 a morbidity and mortality conference takes place once per month in the Department I of Internal Medicine of the university hospital of Cologne. Cases with unexpected death, unexpected complications or medical errors are discussed. The primary goal is to create an open and confidential forum for doctors, where errors can be discussed without any assignment of guilt. The uncovering of structural problems frequently leads to direct improvements in patient care. Furthermore, the conference can play an important role in medical education.