SUMMARYThis in vitro study tested the effects of two different ceramic thicknesses, two preparation designs and two different luting agents on the marginal integrity and fracture resistance of partial ceramic crowns (PCC). Eighty extracted human molars were prepared according to the following preparation designs: a) Coverage of functional cusps/butt joint (n=40), b) Horizontal reduction of functional cusps (n=40). PCC (Vita Mark II, Cerec3 System) were fabricated and the ceramic thickness of the functional cusps was adjusted to 1): 0.5-1.0 mm and 2): 1.5-2.0 mm. PCC were adhesively luted to the cavities with either Excite/VariolinkII (VL) or RelyX Unicem (RX). The specimens were exposed to thermocycling and central mechanical loading (5000 x 5°C-55°C; 30 second/cycle; 50,0000 x 72.5N, 1.6Hz). For fracture resistance and the marginal integrity of adhesively bonded partial ceramic crowns (PCC), the choice of ceramic thickness and luting material are more important than preparation design. PCC fabricated from industrially sintered feldspathic ceramic should have at least a thickness of 1.5-2.0 mm in stress bearing areas. -test. Dye penetration data indicated that ceramic thickness and luting agent had a statistically significant influence upon marginal integrity in general, irrespective of all other parameters (ERM): RX showed significantly lower microleakage along the RL interface than VL. VL revealed significantly lower microleakage at the TL interface than RX. Fifteen PCC of group 1 (0.5-1.0 mm) and two PCC of group 2 (1.5-2.0 mm) were fractured after thermocycling and central mechanical loading, with the difference being statistically significant. PCC fabricated from industrially sintered feldspathic ceramic should have at least a thickness of 1.5-2.0 mm in stress-bearing areas.