In this article, we used High Angular Resolution Diffusion Imaging (HARDI) with advanced anatomically constrained particle filtering tractography to investigate the role of the arcuate fasciculus (AF) and the middle longitudinal fasciculus (MdLF) in speech perception in noise in younger and older adults. Fourteen young and 15 elderly adults completed a syllable discrimination task in the presence of broadband masking noise. Mediation analyses revealed few effects of age on white matter (WM) in these fascicles but broad effects of WM on speech perception, independently of age, especially in terms of sensitivity and criterion (response bias), after controlling for individual differences in hearing sensitivity and head size. Indirect (mediated) effects of age on speech perception through WM microstructure were also found, after controlling for individual differences in hearing sensitivity and head size, with AF microstructure related to sensitivity, response bias and phonological priming, and MdLF microstructure more strongly related to response bias. These findings suggest that pathways of the perisylvian region contribute to speech processing abilities, with relatively distinct contributions for the AF (sensitivity) and MdLF (response bias), indicative of a complex contribution of both phonological and cognitive processes to age‐related speech perception decline. These results provide new and important insights into the roles of these pathways as well as the factors that may contribute to elderly speech perception deficits. They also highlight the need for a greater focus to be placed on studying the role of WM microstructure to understand cognitive aging.

The ability to perceive speech in noise (SPiN) declines with age. Although the etiology of SPiN decline is not well understood, accumulating evidence suggests a role for the dorsal speech stream. While age‐related decline within the dorsal speech stream would negatively affect SPiN performance, experience‐induced neuroplastic changes within the dorsal speech stream could positively affect SPiN performance. Here, we investigated the relationship between SPiN performance and the structure of the arcuate fasciculus (AF), which forms the white matter scaffolding of the dorsal speech stream, in aging singers and non‐singers. Forty‐three non‐singers and 41 singers aged 20 to 87 years old completed a hearing evaluation and a magnetic resonance imaging session that included High Angular Resolution Diffusion Imaging. The groups were matched for sex, age, education, handedness, cognitive level, and musical instrument experience. A subgroup of participants completed syllable discrimination in the noise task. The AF was divided into 10 segments to explore potential local specializations for SPiN. The results show that, in carefully matched groups of singers and non‐singers (a) myelin and/or axonal membrane deterioration within the bilateral frontotemporal AF segments are associated with SPiN difficulties in aging singers and non‐singers; (b) the structure of the AF is different in singers and non‐singers; (c) these differences are not associated with a benefit on SPiN performance for singers. This study clarifies the etiology of SPiN difficulties by supporting the hypothesis for the role of aging of the dorsal speech stream.

Limited evidence has shown that practising musical activities in aging, such as choral singing, could lessen age-related speech perception in noise (SPiN) di culties. However, the robustness and underlying mechanism of action of this phenomenon remain unclear. In this study, we used surface-based morphometry combined with a moderated mediation analytic approach to examine whether singing-related plasticity in auditory and dorsal speech stream regions can mitigate age-related SPiN di culties. 36 choral singers and 36 non-singers aged 20-87 years underwent cognitive, auditory, and SPiN assessments. Our results provide important new insights into experience-dependent plasticity by revealing that, under certain conditions of practice, amateur choral singing is associated with age-dependent structural plasticity within auditory and dorsal speech regions, which is associated with better SPiN performance in aging. Speci cally, the conditions of practice that were bene cial for SPiN included frequent weekly practice at home, several hours of weekly group singing practice, singing in multiple languages, and having received formal singing training.These results suggest that the effect of amateur choral singing on SPiN is related to a dual mechanism involving auditory processing and auditory-motor integration and may be dose dependent, with more intense singing associated with greater bene t. Our results thus reveal that the relationship between musical practice and SPiN is complex, and underscore the importance of considering musical practice behaviours in understanding the effects of musical activities on the brain-behaviour relationship.

Objective: Evidence suggests that hearing loss increases the risk of cognitive impairment. However, the relationship between hearing loss and cognition can vary considerably across studies, which may be partially explained by demographic and health factors that are not systematically accounted for in statistical models.Design: Middle-aged to older adult participants (N = 149) completed a web-based assessment that included speech-in-noise (SiN) and self-report measures of hearing, as well as auditory and visual cognitive interference (Stroop) tasks. Correlations between hearing and cognitive interference measures were performed with and without controlling for age, sex, education, depression, anxiety, and selfrated health. Results:The risk of having objective SiN difficulties differed between males and females. All demographic and health variables, except education, influenced the likelihood of reporting hearing difficulties. Small but significant relationships between objective and reported hearing difficulties and the measures of cognitive interference were observed when analyses were controlled for demographic and health factors. Furthermore, when stratifying analyses for males and females, different relationships between hearing and cognitive interference measures were found. Self-reported difficulty with spatial hearing and objective SiN performance were better predictors of inhibitory control in females, whereas self-reported difficulty with speech was a better predictor of inhibitory control in males. This suggests that inhibitory control is associated with different listening abilities in males and females. Conclusions:The results highlight the importance of controlling for participant characteristics when assessing the relationship between hearing and cognitive interference, which may also be the case for other cognitive functions, but this requires further investigations. Furthermore, this study is the first to show that the relationship between hearing and cognitive interference can be captured using web-based tasks that are simple to implement and administer at home without any assistance, paving the way for future online screening tests assessing the effects of hearing loss on cognition.