Introduction
Given the COVID19 pandemic, it is crucial to understand the underlying behavioral determinants of SARS-CoV-2 vaccine hesitancy in patients with autoimmune or inflammatory rheumatic diseases AIIRD. We aimed to analyze patterns of behaviors regarding SARS-CoV-2 vaccination in AIIRD patients, as a mean to identify pragmatic actions to increase vaccine coverage in this population.
Methods
Data of 1258 AIIRD patients were analyzed using univariate and multivariate logistic regression models, to identify variables associated independently with the willingness to get vaccinated against SARS-CoV-2. Subsets of patients showing similar behaviors towards SARS-CoV-2 vaccination were characterized using cluster analysis.
Results
Hierarchical cluster analysis identified 3 distinct clusters of AIIRD patients. Three predominant patients’ behavior towards SARS-COV-2 vaccination: ‘voluntary’, ‘hesitant’ and ‘suspicious’ were identified. While vaccine willingness was significantly different across the 3 clusters p< 0.0001, there was no difference regarding the fear to get COVID-19 p= 0.11, the presence of co-morbidities p= 0.23, the use of glucocorticoids p= 0.21 or the immunocompromised status p= 0.63. However, patients from cluster #3 ‘suspicious’ were significantly more concerned about vaccination, the use of a new vaccine technology, the lack of hindsight regarding COVID vaccination and potential financial links with pharmaceutical companies p< 0.0001 in all than in the other 2 clusters.
Discussion
Importantly, the differences between patients’ behaviors are not related to the fear of getting COVID-19 or to any state of frailty, but point out to specific concerns about vaccination. This study may serve as a basis for improved communication, to increase COVID-19 vaccine coverage in AIIRD patients.
Synthetic procedures are described for the preparation of cationic derivatives of the formula [( ' )2(82 2)(µ-8)(µ-8 )]+, where Cp' = C6H5 (a), C5H4Me (b), or C5Mes (c). Spectroscopic data for the protonated complexes are reported, and p values for the µ-SH ligands have been determined in acetonitrile. Oxidation of the protonated complexes results in the formation of a dicationic derivative of the formula [( ' (µ-8))282 2]22+, 2. Both the triflate and tetrafluoroborate salts of 2b have been characterized by X-ray diffraction studies. The triflate salt crystallized in space group C2/c with o = 35.498 (10) A,b = 14.823 (7) Á, c = 17.246 (5) Á, and ß = 115.51 (2)°. The tetrafluoroborate salt crystallized in space group P2Jn with o = 11.476 (5) A, b = 13.843 (6) A, c = 12.577 (4) A, and ß = 112.97 (3)°. The structures confirm that two dinuclear units have interacted through formation of a S-S bond between µ-sulfido ligands. The reaction of hydrogen (1 atm) with 2 at room temperature resulted in the hydrogenolysis of the intermolecular S-S bond and the formation of 1. Other reactions of 2 have been Characterized that indicate that 2 functions as an effective hydrogen atom acceptor. listings of observed and calculated structure factors (35 pages). Ordering information is given on any current masthead page. NMR and X-ray Studies of Renta-and Hexaborane Alkyl Derivatives Involving [3.3.1] and [3.3.2] Ring Systems
The reduction of imines to amines via transfer hydrogenation was achieved promoted by phosphine‐free manganese(I) catalyst. Using isopropanol as reductant, in the presence of tBuOK (4 mol %) and manganese complex [Mn(CO)3Br(κ2N,N‐PyCH2NH2)] (2 mol %), a large variety of aldimines (30 examples) were typically reduced in 3 hours at 80 °C with good to excellent yield.
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