We report a simple protocol for the copper-catalyzed
hydrothiolation
of N-unsaturated precursors, i.e., allenamides, enamides, and ynamides,
under mild conditions. This method proceeds with a low loading of
a commercially available Cu(CH3CN)4PF6 catalyst and enables the room-temperature transformation of a wide
range of aromatic and aliphatic thiols into allylic or vinylic thioethers,
1,3-dithioethers, and thioaminals with good regio- and stereoselectivity.
A ligand and base free copper catalyzed synthetic methodology for the efficient alpha-arylation of aromatic ketones has been developed. The reaction of the ketone-derived silyl enol ethers with diaryliodonium salts led to the intermolecular C-C coupling displaying high functional group tolerance with a low catalyst loading.<br>
A ligand and base free copper catalyzed synthetic methodology for the efficient alpha-arylation of aromatic ketones has been developed. The reaction of the ketone-derived silyl enol ethers with diaryliodonium salts led to the intermolecular C-C coupling displaying high functional group tolerance with a low catalyst loading.<br>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.