upuytren disease is a common fibroproliferative hand disease, with a worldwide prevalence of approximately 8.2%. 1 Although frequently regarded as benign and not requiring prevention, the fixed flexion deformity characterizing Dupuytren disease progression causes significant disability. 2 There are currently no preventative therapies, and surgical management is not without risk. Recurrence is common, and Background: Dupuytren disease is associated with significant comorbidity and mortality, and it has no existing prevention strategies. It is unclear which modifiable risk factors are most amenable for prevention. This study aimed to determine the strength of modifiable risk factors for Dupuytren disease, and to investigate associations with other diseases. Methods: Using UK Biobank data, this case-control study analyzed the association between phenotypic variables and Dupuytren disease through multivariable logistic regression. Exposures assessed were age, sex, body mass index, waist-to-hip ratio, Townsend deprivation index, smoking status, alcohol intake, diabetes mellitus, hypertension, cancer, liver disease, respiratory disease, rheumatoid arthritis, epilepsy, psoriasis, and gout.
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