Anatomical, stimulation, and lesion data have suggested a homology between the rat frontal orienting fields (FOF) (centered at +2 AP, ±1.3 ML mm from Bregma) and primate frontal cortices such as the frontal or supplementary eye fields. We investigated the functional role of the FOF using rats trained to perform a memory-guided orienting task, in which there was a delay period between the end of a sensory stimulus instructing orienting direction and the time of the allowed motor response. Unilateral inactivation of the FOF resulted in impaired contralateral responses. Extracellular recordings of single units revealed that 37% of FOF neurons had delay period firing rates that predicted the direction of the rats' later orienting motion. Our data provide the first electrophysiological and pharmacological evidence supporting the existence in the rat, as in the primate, of a frontal cortical area involved in the preparation and/or planning of orienting responses.
Lewis' Best System Analysis (BSA) of laws of nature is often criticized on the grounds that what it means to be the "best" system is too subjective for an analysis of lawhood. Recent proponents of the BSA have embraced the view's close connection to the particulars of scientific practice despite the objection. I distinguish two compatible versions of the objection: one opposed to mind or subject dependence and the other opposed to relativity. The BSA can answer both. Answering the antirelative version of Armstrong's objection requires that the BSA be no more or less relative than is required by scientific practice. A spectrum of relativity is introduced with extremes of minimally and maximally relative variants of the BSA, and extant variants of the BSA are located on it. Lastly, I sketch what work remains to be done with respect to Armstrong's objection by BSA proponents depending on where in the spectrum of relativity they hope to locate their view.
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