Drechslera gigantea, a potential mycoherbicide of grass weeds, was isolated in Florida from naturally infected large crabgrass (Digitaria sanguinalis); it produces phytotoxic metabolites in liquid culture. The main metabolite was identified by spectroscopic methods and optical properties as ophiobolin A (1), a well-known phytotoxic sesterterpene produced by several phytopathogenic fungi of important crops and already extensively studied for its interesting biological activities. The other three minor metabolites proved to be related to ophiobolin A and were identified using the same techniques as 6-epi-ophiobolin A and 3-anhydro-6-epi-ophiobolin A (2 and 3) and ophiobolin I (4). Assayed on punctured detached leaves of several grass and dicotyledon weeds, ophiobolin A proved to be on average more phytotoxic as compared to the other related compounds. Some structural features appear to be important for the phytoxicity, such as the hydroxy group at C-3, the stereochemistry at C-6, and the aldehyde group at C-7. Furthermore, grass weeds usually proved to be more sensitive to the phytotoxins than dicotyledons, on which ophiobolin A caused the appearance of large necrosis even at the lowest concentration assayed. This is the first report about the production of ophiobolins from D. gigantea and of the proposed use as potential natural herbicides against grass weeds.

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A new phytotoxic geranylcyclohexenetriol, named phomentrioloxin, was isolated from the liquid culture of Phomopsis sp., a fungal pathogen proposed for the biological control of Carthamus lanatus, a widespread and troublesome thistle weed belonging to the Asteraceae family causing severe crop and pastures losses in Australia. The structure of phomentrioloxin was established by spectroscopic, X-ray, and chemical methods as (1S,2S,3S,4S)-3-methoxy-6-(7-methyl-3-methylene-oct-6-en-1-ynyl)cyclohex-5-ene-1,2,4-triol. At a concentration of 6.85 mM, the toxin causes the appearance of necrotic spots when applied to leaves of both host and nonhost plants. It also causes growth and chlorophyll content reduction of fronds of Lemna minor and inhibition of tomato rootlet elongation. Finally, in preliminary bioassays, phomentrioloxin did not show any antibacterial, fungicidal, or zootoxic activities.

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Emerging infectious diseases (EIDs) caused by plant pathogens can develop into unexpected and very serious epidemics, owing to the influence of various characteristics of the pathogen, host and environment. Devastating epidemics, having social implications by increasing the rate of urbanization, occurred in the past in Europe, and many other EIDs still occur with high frequency in developing countries. Although the ability to diagnose diseases and the technologies available for their control are far greater than in the past, EIDs are still able to cause tremendous crop losses, the economic and social impact of which, in developing countries, is often underestimated. In the present article, four of the most important EIDs in developing countries are considered from the standpoint of their origin, characteristics, symptoms, mode of spread, possible control strategies, economic impact and the socio-economic consequences of their dissemination. They are Cassava Mosaic Virus Disease,capable of reducing yields by 80–90% and causing the suspension of cassava cultivation in many areas of East Africa; Striga hermonthica, a parasitic weed affecting cereals in an area of at least 5 million hectares in Sub- Saharan Africa; Xanthomonas Wilt of Banana, a bacterial disease that caused around 50% yield losses at the beginning of 21st century in Uganda and is threatening the food security of about 70 million people owing to its impact on an important staple crop; and race Ug99 of the rust fungus Puccinia graminis f. sp. tritici, which is having a tremendous impact on wheat in Uganda, and is also threatening most of the wheat-growing countries of the world

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