From nciJ/eUumol c~lr~~rtd of bucgic~l spccinrcnx of human htrpe intestine WC iaalatad two pptidcs, in approximately equal amountr, thtrr. ~&led with an antiserum agninrt pereinc grlrnin. By amino acid analyxin, aqusncc analysis and mass apceerramerry, rhc ltupcr artha two pcptidcr was fkund to consist or 30 am;no ncid residues, the sequence or which wax idcnticul to Ihat af pureinc @min oxeepr Par rhc iWewiny substitutions: Consistent with its widespread localization galanin controls various biological activities: it regulates growth hormone release, it contracts smooth muscle of the gastrointestinal and genitourinary tract, it modulates irisulin release and may be involved in the control of adrenal secretion [2,3]. By means of molecular biology techniques the structures of rat and bovine galanin have also been deduced [4,5].The three animal forms are identical with respect to the first IS residues but differ at several positions in the C-terminal part.. The sequence of human galanin is not known, but the molecule does not react with antisera against the C-terminal region of porcine galanin, GAL-LI, galanin-like immunoreactivity; HPLC, high performance liquid chromatography; ACN, acetonitrile; TFA, trifluoroacetic acid; HFBA, heptafluorobutyric acid; PTH, phenylthiohydantoin; PDMS, plasma desorption mass spectrometryPublished by Elsevier Science Publishers B. V.
This study highlights a significant economic burden related to CKD and an increase in direct healthcare costs associated with the start of dialysis, pointing to the importance of prevention programs and early diagnosis.
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