Scleromyxedema or lichen myxedematosus is a rare papular mucinosis of chronic and progressive course and unknown etiology. It is commonly associated with monoclonal gammopathy and may show extracutaneous manifestations, affecting the heart, lung, kidney, and nerves. The diagnosis is based on four criteria: generalized papular and sclerodermoid lesions; mucin deposition, fibroblast proliferation, and fibrosis in the histopathology; monoclonal gammopathy; and no thyroid disorders. This article reports the case of a scleromyxedema patient with a recent history of acute myocardial infarction and monoclonal gammopathy.

Objectives: This study aimed on analyzing vitamin D serum levels and its impact on oocyte quality in patients undergoing in vitro fertilization (IVF) procedures at a human reproduction laboratory located in Curitiba, Brazil. Methods: This article is an observational cross-sectional study of retrospective data collected from the medical history of patients that have undergone IVF treatment between January 2015 and December 2015 in a specialized clinic (Clínica de Reprodução Dr. Ricardo Beck da Maternidade Curitiba) located in Curitiba, Brazil. Different vitamin D levels where compared with a variety of oocyte qualities and in vitro cleavage percentage. Results: We identified a prevalence of deficient (≤ 20 ng/mL) and insufficient (21-29 ng/mL) vitamin D levels among the patients in this study. No evidence was found that could confirm an effect of vitamin D on oocyte quality or in vitro cleavage percentage. Conclusion: Age has been shown to be an important factor in altering the number of oocytes available after pharmacological induction and oocytes with adequate quality for implantation at the end of the in vitro cycle. Due to the importance of the subject, further studies are essential for a better understanding of the effect of vitamin D on human fertility and IVF procedures.

Objectives: To verify the in vitro fertilization success rates in patients with thrombophilia and compare it to a control group. Material and methods: Analysis of the records of patients submitted to in vitro fertilization between January 2011 and December 2014. The study group was comprised of 47 patients with thrombophilia and the control group was comprised of 223 patients without thrombophilia. Results: The thrombophilic patients age varied from 28 to 48 years, with average age of 35 years. The number of fertilization attempts varied from 1 to 6, with average of 2.11. The control group age varied from 22 to 63 years, with average of 36 years. The number of attempts varied from 1 to 4, with average of 1.28. Only 6.3% of the positive beta hCG results belonged to thrombophilic patients, while 32.7% of the negative results belonged to the study group. A high incidence of MTHFR mutations was found (61.7%), but the frequency of the factor V Leiden was not significant (2.1%). Conclusions: The patients with thrombophilia have lower success rates on in vitro fertilization procedures. The most frequent mutation was MTHFR C677T. There was no prejudice on the quality or quantity of oocytes.