PurposePoor adherence to therapy and the failure of current smoking cessation programs demonstrate that the current management of COPD can be improved, and it is necessary to educate physicians about new approaches for taking care of patients. Parallel chart is a narrative medicine tool that improves the doctor–patient relationship by asking physicians to write about their patients’ lives, thereby encouraging reflective thoughts on care.Patients and methodsBetween October 2015 and March 2016, 50 Italian pulmonologists were involved in the collection of parallel charts of anonymous patients with COPD. The narratives were analyzed according to the Grounded Theory methodology.ResultsIn the 243 parallel charts collected, the patients (mean age 69 years, 68% men) are described as still active and as a resource for their families (71%). The doctor–patient relationship started as difficult in 50% of cases, and younger age and smoking were the main risk factors. The conversations turned positive in 78% of narratives, displaying deeper mutual knowledge, trust for the clinicians’ ability to establish effective therapy (92%), support efforts to quit smoking (63%), or restore patients’ activities (78%).ConclusionAll the physicians concurred that the adoption of innovative parallel charts was useful for improving clinical care and worthy of official inclusion in protocols for the management of COPD.

Background The The Roadmap Using Story Telling project used a narrative medicine (NM) framework to assess the perspectives of people with heart failure (HF), their informal caregivers and HF specialists of the impact of HF on the daily life of patients and their carers. Methods Italian HF specialists participated on a voluntary basis, completing their own narratives, and inviting patients and their caregivers to write anonymously about their experiences, all on a dedicated online platform. The narratives were analyzed according to standard NM methodology. Results 82 narratives were collected from patients, 61 from caregivers, and 104 from HF specialists. Analysis of the three points of view revealed the extent of the burden of illness on the entire family, particularly that of the caregiver. The impact was mainly experienced as emotional and social limitations in patients’ and their caregivers’ daily lives. The analysis of all three points of view highlighted a strong difference between how HF is perceived by patients, caregivers, and HF specialists. Conclusions This NM project illustrates the complex issues of living with HF and gave insights to integrate three different perspectives into the HF pathway of care.

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Background: The TRUST (The Roadmap Using Story Telling) project used a Narrative Medicine (NM) framework to assess the perspectives of people with heart failure (HF), their informal caregivers and HF specialists of the impact of heart failure (HF) on the daily life of patients and their carers. Methods: Italian HF specialists participated on a voluntary basis, completing their own narratives, and inviting patients and their caregivers to write anonymously about their experiences, all on a dedicated online platform. The narratives were analyzed according to standard NM methodology. Results: 82 narratives were collected from patients, 61 from caregivers, and 104 from HF specialists. Analysis of the three points of view revealed the extent of the burden of illness on the entire family, particularly that of the caregiver. The impact was mainly experienced as emotional and social limitations in patients’ and their caregivers’ daily lives. The analysis of all three points of view highlighted a strong difference between how HF is perceived by patients, caregivers, and HF specialists. Conclusions: This NM project illustrates the complex issues of living with HF and gave insights to integrate three different perspectives into the HF pathway of care.

Inclisiran is a synthetic small-interfering RNA (siRNA) that works with the RNA interference (RNAi) mechanism. SiRNA binds its target mRNA, leading to silencing the protein synthesis by the related mRNA degradation. Inclisiran is designed to bind solely PCSK9 mRNA, decreasing PCSK9 expression, thus leading to lower LDL-C level. Several chemical modifications were added to obtain a stable compound delivering a rapid effect and generally well tolerated [Khvorova A. Oligonucleotide therapeutics—a new class of cholesterol-lowering drugs. N Engl J Med 2017; 376 4–7]. High cholesterol levels and prolonged time of exposure enhance risk of new or recurrent CV events, therefore also timing became crucial for atherosclerotic cardiovascular disease (ASCVD) patients [Ference BA, Graham I, Tokgozoglu L, et al. Impact of lipids on cardiovascular health: JACC health promotion series. J Am Coll Cardiol 2018; 72 1141–1156]. Therefore, an early and effective LDL-C lowering effect is positively correlated with CV risk reduction, together with the life-long LDL-C reduction that will impact definitively on the global CV risk [Cohen JC, Boerwinkle E, Mosley TH Jr, et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006; 354 1264–1272]. The siRNA conjugation with a triantennary GalNAC leads to a specific targeted hepatic delivery therefore, the 284 mg inclisiran dose is undetectable in blood stream after 24–48 h from the subcutaneous injection [Wright RS, Collins MG, StoekenbroekRM, et al. Effects of renal impairment on the pharmacokinetics, efficacy, and safety of inclisiran: an analysis of the ORION-7 and ORION-1 studies. Mayo Clin Proc 2020; 95 77–89]. The LDL-C lowering effect starts early upon the hepatic cell entry (24–48 h) and the LDL-C level drop is already significant at 14 days post injection, and by Day 30 the mean reduction is about 50%, as shown in the ORION-1 phase II trial [Ray KK, Landmesser U, Leiter LA, et al. Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol. N Engl J Med 2017; 376 1430–1440]. Other chemical modifications at the siRNA back-bone level, protect inclisiran from degradation by liver nucleases, which may occur upon the hepatic cell uptake. In the cytoplasm, RNAi mechanism occurs by the siRNA—RISC protein complex coupling. Physiologically, this bond last for long and the inclisiran back-bone modifications further enhance the complex stability [Khvorova A. Oligonucleotide therapeutics—a new class of cholesterol-lowering drugs. N Engl J Med 2017; 376 4–7]. Moreover, one siRNA-RISC complex has an effect on multiple PCSK9 mRNA units, allowing inclisiran administration twice per year (after initial dose at baseline and 3 months), granting an early, sustained and effective LDL-C level reduction that lasts for 6 months. A pooled analysis of the 3 phase III trials (ORION-9/10/11) shows a time averaged (18 months) LDL-C reduction of 50.5% on top of therapy with statins±ezetimibe [Wright RS, Ray KK, Raal FJ, et al. Pooled patient-level analysis of inclisiran trials in patients with familial hypercholesterolemia or atherosclerosis. J Am Coll Cardiol 2021; 77 1182–1193]. Inclisiran provides effective evidence-based results on lowering LDL-C levels in different high CV risk populations (HeFH/established ASCVD/ASCVD-risk equivalent), which is demonstrated to be crucial for the reduction of patients’ CV risk. Furthermore, the twice per year administrations may positively improve adherence, thereby simplifying patient management and control during follow-up. Based on these findings, we are stepping into a new era of biologic therapeutics, where inclisiran represents the new, effective and safe therapeutic candidate for lowering LDL-C levels.