The authors followed the frequency of fragrance contact sensitization in Hungary in a multicentre study in the years 1998 and 1999. A total of 3,604 patients were tested with fragrance mix (FM), and positive reactions were observed in 294 (8.2%). In 160 FM hypersensitive patients, the study was continued with patch testing of the mix constituents (cinnamic alcohol, cinnamic aldehyde, eugenol, amyl cinnamic aldehyde, hydroxycitronellal, geraniol, isoeugenol, oak moss absolute). Of the patients tested, 70.6% produced positive reactions to the constituents. FM contact sensitization was mainly observed in female patients (74.4%). The incidence of contact urticaria in FM hypersensitive patients was 6.1%. Simultaneous patch test trials of other environmental contact allergens, in both early and late evaluations, mainly confirmed hypersensitivity reactions to balsams. Female dominance of hypersensitivity reactions observed during testing the individual components of the mix was striking (82.4%). In positive skin reactions, cinnamic alcohol, isoeugenol and oak moss provoked skin symptoms most frequently. We also tested the 104 patients who produced negative reactions to FM with the constituent individual allergens, with 11.9% positive incidence. The clinical symptoms of the patients were above all manifest in the form of contact eczema, located on the hands, face, eyelids and axillae. With this study, the authors, members of the Hungarian Contact Dermatitis Research Group, call attention to one of the most frequent allergens in the environment.
Közép-magyarországi melanoma esetek longitudinális megfigyelésének kiértékelése (egy centrumban) 35 év távlatában. Interferon kezelések hatása (retrospektív tanulmány) Assesment of 35 years longitudinal observations on melanoma patients in a single center of Hungary's central region. Effect of interferon immunotherapy (retrospective study)
Authors report the case of a79 year old man. After weakness, paraesthesia and walking disturbances developing within weeks he was admitted to the Neurology Department of our institution. Upon negativity of Computed Tomography the Magnetic Resonance Investigation of the spinal cord revealed space constrictor process corresponding to thoracic vertebrae X- XI. This mass wasremoved surgically. Histology supplemented by immuno-histochemistry had proved malignant melanoma. Genetic test out of the removed neoplastic tissue was negative to BRAF-V600 E. The repeated thoroughly performed checks on the entire integument as well as negativity of the ophthalmic status has raised the possibility of primary melanoma originated from the spinal cord. No lymph node metastasiswas detected.Aftersurgery targeted X-ray irradiation was performed, followed by Pembrolizumab administration in monotherapy. This treatment was, however suspended due to rapidly developing side effects. As next Carboplatin therapy was started which was stopped after the 5th cycle due to side effects. The temporary remission has lasted for 7 months but the initial symptoms had returned with increasing pain. From this time urinary infection and disturbance of intestinal passage have dominated the clinical picture. Decubital ulceration and sepsis developed and the patient died 21 months after first appearance of clinical symptoms. Extreme rarity and poor survival not exceeding 5 years are characteristics of the of reported cases
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