Narrow Line Seyfert 1 galaxies (NLS1s) are generally considered peculiar objects among the broad class of Type 1 active galactic nuclei, due to the relatively small width of the broad lines, strong X-ray variability, soft X-ray continua, weak [O iii], and strong Fe ii line intensities. The mass M BH of the central massive black hole (MBH) is claimed to be lighter than expected from known MBH-host galaxy scaling relations, while the accretion rate onto the MBH larger than the average value appropriate to Seyfert 1 galaxies. In this Letter, we show that NLS1 peculiar M BH and L/L Edd turn out to be fairly standard, provided that the broad line region is allowed to have a disc-like, rather than isotropic, geometry. Assuming that NLS1s are rather "normal" Seyfert 1 objects seen along the disc axis, we could estimate the typical inclination angles from the fraction of Seyfert 1 classified as NLS1s, and compute the geometrical factor relating the observed FWHM of broad lines to the virial mass of the MBH. We show that the geometrical factor can fully account for the "black hole mass deficit" observed in NLS1s, and that L/L Edd is (on average) comparable to the value of the more common broad line Seyfert 1 galaxies.

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Single photon emission computed tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection efficiency and energy acceptance are limited and fixed by the system's geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT has been investigated for several years. In this study we compare a commercial SPECT-Anger device, the General Electric HealthCare Infinia system with a High Energy General Purpose (HEGP) collimator, and the Compton camera prototype under development by the French collaboration CLaRyS, through Monte Carlo simulations (GATE-GEANT4 Application for Tomographic Emission-version 7.1 and GEANT4 version 9.6, respectively). Given the possible introduction of new radio-emitters at higher energies intrinsically allowed by the Compton camera detection principle, the two detectors are exposed to point-like sources at increasing primary gamma energies, from actual isotopes already suggested for nuclear medicine applications. The Compton camera prototype is first characterized for SPECT application by studying the main parameters affecting its imaging performance: detector energy resolution and random coincidence rate. The two detector performances are then compared in terms of radial event distribution, detection efficiency and final image, obtained by gamma transmission analysis for the Anger system, and with an iterative List Mode-Maximum Likelihood Expectation Maximization (LM-MLEM) algorithm for the Compton reconstruction. The results show for the Compton camera a detection efficiency increased by a factor larger than an order of magnitude with respect to the Anger camera, associated with an enhanced spatial resolution for energies beyond 500 keV. We discuss the advantages of Compton camera application for SPECT if compared to present commercial Anger systems, with particular focus on dose delivered to the patient, examination time, and spatial uncertainties.

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Objective: To describe the molar movements and skeletal changes associated with Pendulumfixed appliance treatment and the long-term postretention period. Subjects and Methods: The treatment sample consisted of 76 Class II patients, 35 males and 41 females. Lateral cephalograms were obtained at the start of treatment (T1); the end of distalization (T2); the end of orthodontic fixed appliance therapy (T3); and long-term observation (7 years 2 months later; T4). Mean age was 12 years 11 months at T1, 13 years 8 months at T2, 15 years 4 months at T3, and 22 years 5 months at T4. The average amount of Class II molar relationship was 3.1 mm, with a mean overjet of 5.9 mm at the beginning of treatment. A paired t-test was used to identify significant between-group differences between T2-T4 and T3-T4. Results: Distal molar movement was obtained during the distalization phase (T2), and more than half of the distalizing effect was maintained at the end of maxillary growth (T4). Most of the relapse occurred during fixed appliance therapy (T3), whereas no significant change was detected in the postretention period (T4). The molar relationship did not show any significant difference between T2 and T4. The vertical facial dimension increased during the distalization phase (T2) and fixed appliance therapy (T3) but returned to the initial values during the postretention period (T4). Conclusions: The Pendulum appliance induces significant dentoalveolar effects, which can be partially maintained during the long-term period. The Class I molar relationship does not change during completion of individual growth. Increase in vertical facial dimension represents a temporary effect. (Angle Orthod. 2013;83:447-454.)

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Abstract-. The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne del'hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection efficiency for carbon or proton beams giving time and position measurement at 100 MHz count rates (beam tagging hodoscope). High radiation hardness and intrinsic electronic properties make diamonds reliable and very fast detectors with a good signal to noise ratio. Commercial Chemical Vapor Deposited (CVD) polycrystalline, heteroepitaxial and monocrystalline diamonds were studied. Their applicability as a particle detector was investigated using α and β radioactive sources, 95 MeV/u carbon ion beams at GANIL and 8.5 keV X-ray photon bunches from ESRF. This facility offers the unique capability of providing a focused (~1 µm) beam in bunches of 100 ps duration, with an almost uniform energy deposition in the irradiated detector volume, therefore mimicking the interaction of single ions. A signal rise time resolution ranging from 20 to 90 ps rms and an energy resolution of 7 to 9% were measured using diamonds with aluminum disk shaped surface metallization. This enabled us to conclude that polycrystalline CVD diamond detectors are good candidates for our beam tagging hodoscope development. Recently, double-side stripped metallized diamonds were tested using the XBIC (X Rays Beam Induced Current) set-up of the ID21 beamline at ESRF which permits us to evaluate the capability of diamond to be used as position sensitive detector. The final detector will consist in a mosaic arrangement of double-side stripped diamond sensors read out by a dedicated fast-integrated electronics of several hundreds of channels. therapy. Ions deposit a large fraction of the dose at the end of their path, in the Bragg peak. Compared to conventional X-ray radiotherapy, hadron therapy allows a more efficient dose delivery in the tumor, with a reduction of the dose deposited in the nearby healthy organs. The conformation of the deposited dose to the tumor volume is provided by distributing Bragg peaks in this volume, either spot by spot, or by means of passive scattering and energy degradation. However, since multiple sources of uncertainty on the ion range may cause deviations from the planned dose distribution [1], online control of the ion range is desired in order to reduce safety margins and optimize the ballistic advantage of ion therapy.During an irradiation with ion beams, nuclear reactions occur for part of the projectiles along their path in the patient body, and photons in the range 1-10 MeV are emitted almost isotropically within much less than a picosecond after the reactions. It has been shown experimentally that the longitudinal distribution of such prompt-gamma production is highly correlated to the primary ion range

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